The immunologic competence of mouse thymus cells measured by the graft vs. host spleen assay.

The Immunologic Competence of Mouse Thymus Cells Measured by the Graft vs . Host Spleen

Contribution of a Thymic Humoral Factor to the Development of an Immunologically Competent Population from Cells of Mouse Bone Marrow

The hypothesis that cells located in mouse bone marrow can acquire immunological competence by a process that involves interaction with a noncellular component of the thymus was tested using an in vitro assay of graft-versus-host reactivity as a criterion of cell competence. When suspensions of C57BL bone marrow cells were incubated in thymus extract and injected into mice incapable of inducing...

Reactivation in Vitro of Immunocompetence in Irradiated Mouse Spleen

The restoration of immunological competence to irradiated adult mouse spleen was studied using an in vitro assay system. Competence of the spleen to evoke a graft versus host reaction in vitro was lost upon sublethal irradiation (550 R). Regeneration of immune competence occurred when such spleens were grown for 2-3 days in the presence of thymus tissue, but not when grown in the presence of a ...

Studies on the Role of the Thymus in Immunobiology

The immunologic competence of spleen cells of mice, as assessed by their graft versus host capabilities, increases to 35 days of age and beyond. Thymectomy at any point along this continuum of development produces "immunologic arrest;" the peripheral lymphoid tissues of such mice do not show significant increases in activity as the animals mature, nor is there appreciable loss of activity up to...

Immunocompetence of Spleen Cells from Neonatally Thymectomized Mice Conferred in Vitro by a Syngeneic Thymus Extract

Impaired immunological competence of spleen cells from neonatally thymectomized C57B1/6 young adult mice was apparent when these cells were tested in an in vitro graft-versus-host assay. Spleen cell inocula prepared from thymectomized mice did not induce enlargement of (C3H/eb x C57BI/6)F(1) newborn spleen explants, whereas the same number of cells from intact donors consistently initiated sple...