High-Throughput Interrogation of Ligand Binding Mode Using a Fluorescence-Based Assay**
نویسندگان
چکیده
Probing the pocket: A high-throughput fluorescence-based thermal shift (FTS) assay utilized different forms of a protein (in gray) to establish the binding mode of a ligand (see picture). The assay serves in the rapid evaluation of structure-activity binding-mode relationships for a series of ligands of Plk1, an important target of anticancer therapy.
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عنوان ژورنال:
دوره 51 شماره
صفحات -
تاریخ انتشار 2012