Characterization and real-time imaging of the FTLD-related protein aggregation induced by amyloidogenic peptides.
نویسندگان
چکیده
We identify a new amyloidogenic peptide from the glutamine/asparagine-rich region of the FTLD-related protein (TDP-43), which can seed both the full-length and N-terminus-truncated TDP-43. Through the microinjection and real-time fluorescence imaging, we also found that this novel peptide could trigger cell apoptosis and initiate TDP-43 aggregation in the cytosol.
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عنوان ژورنال:
- Chemical communications
دوره 51 41 شماره
صفحات -
تاریخ انتشار 2015