Ini-kction Control and Hospital Epidemiology
نویسنده
چکیده
The major transmissible spongiform encephalopathies (TSEs) of humans include Creutzfeldt-Jakob disease (CJD), kuru, fatal familial insomnia, GerstmannStraussler-Scheinker syndrome, and, within the past 10 years, variant CJD (vCJD). The pathology of these neurodegenerative diseases of the central nervous system is associated with the presence of pathologic prions, an abnormal conformation of a normal cellular protein. Fomites and tissues contaminated with prions, such as dura mater and corneas, can transmit disease to humans. At least six cases of CJD have been attributed to the use of neurosurgical instruments and depth electrodes contaminated with prion-containing neural tissues. These cases of device-associated transmission highlight the challenges and data gaps that confront healthcare staff responsible for disinfection and sterilization of hospital equipment. The work described by Yan et al. in the lead article of this issue of Infection Control and Hospital Epidemiology represents an attempt to address the gap in our knowledge regarding prion decontamination and low-temperature sterilization methods.
منابع مشابه
Ini-kction Control and Hospital Epidlmiology
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تاریخ انتشار 2014