Timeliness of Antibiotic Prophylaxis for Children With Sickle Cell Disease
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چکیده
Spleen damage is a common and crucial characteristic of SCD. A damaged spleen cannot effectively clear bacteria from the blood, leaving SCD patients, particularly young children, highly susceptible to infection. Children with SCD have rates of infection caused by bacterial pneumonia 30-100 times that of children without SCD, and pneumonia vaccines are of limited effectiveness in this age group because of low antibody response. However, twice-daily doses of an antibiotic sharply reduce the incidence of pneumonia in children with SCD.
منابع مشابه
Antibiotic Prophylaxis for Children With Sickle Cell Anemia.
BACKGROUND Children with sickle cell anemia (SCA) are at increased risk for invasive pneumococcal disease; antibiotic prophylaxis significantly reduces this risk. We calculated the proportion of children with SCA who received ≥300 days of antibiotic prophylaxis and identified predictors of such receipt. METHODS Children aged 3 months to 5 years with SCA were identified by the presence of 3 or...
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BACKGROUND Since the publication of the Prophlyactic Penicillin Study II in 1995, the management of penicillin prophylaxis for children with sickle cell disease (SCD) after 5 years of age has been controversial. In this study, we sought to describe current practice patterns of pediatric hematologists related to cessation of penicillin prophylaxis for children with SCD after 5 years of age. PR...
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Sickle cell disease (SCD) is a known inherited hemoglobin disorder featured by the presence of sickle shaped erythrocytes in the blood. It can cause cerebrovascular accident (CVA) in adults and children and is responsible for the majority of the strokes in children. Repeated blood transfusion are often required in an attempt to dilute blood thus reducing the risk of vaso-occlusion and stroke in...
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PURPOSES The purposes of this study were to: (1) investigate the current clinical practice regarding the use of antibiotic prophylaxis by pediatric dentistry residency program directors and pediatric hematologists for children with sickle cell disease (SCD) requiring dental treatment; and (2) evaluate the perceived relative risk of bacteremia following specific dental procedures, as defined by ...
متن کامل[Nasopharyngeal colonization by Streptococcus pneumoniae in children with sickle cell disease receiving prophylactic penicillin].
OBJECTIVES To determine the prevalence of nasopharyngeal pneumococcus colonization in children with sickle cell disease undergoing penicillin prophylaxis, to identify risk factors for colonization and to serotype and determine antibiotic resistance in pneumococci obtained from those children. METHODS Between April 9, 2002 and February 28, 2003, 188 nasopharyngeal swabs were obtained from 98 c...
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تاریخ انتشار 2017