Evaluating preferences for long term wheeze following RSV infection using TTO and best-worst scaling

Background Respiratory Syncytial Virus (RSV) infects 70% of infants under one year, and is a leading cause of infant bronchiolitis-related hospitalizations [1,2]. RSV is a relatively benign, temporary condition, and therefore likely to have limited impact on quality adjusted life years, however, it has potential for long-term consequences such as asthma and wheeze [3,4]. Preferences related to the trade-offs between different long and short term aspects of RSV have not been explored previously, however, deriving preferences for infant health states is very challenging as infants require proxy elicitation of preferences [5-8].