The electroreduction of the disulphide bonds of insulin and other proteins.
نویسندگان
چکیده
Simple disulphides give cathodic waves at the dropping-mercury electrode which are due to their reduction to the corresponding thiols. The polarographic reduction of cystine has been studied by a number of authors (Brdicka, 1933b; Roncato, 1934; Kolthoff & Barnum, 1941; Kolthoff, Stricks & Tanaka, 1955). In acid solution it gives a single wave with a pronounced maximum, and in neutral or alkaline solution a two-step wave. Kolthoff et al. (1955) suggested that the first part of the wave is kinetic and is due to the formation of mercury cysteinate at the surface of the mercury drop:
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عنوان ژورنال:
- The Biochemical journal
دوره 93 1 شماره
صفحات -
تاریخ انتشار 1964