Temperature-modulated fluorescence tomography based on both concentration and lifetime contrast.

نویسندگان

  • Yuting Lin
  • Tiffany C Kwong
  • Linden Bolisay
  • Gultekin Gulsen
چکیده

It is challenging to image fluorescence objects with high spatial resolution in a highly scattering medium. Recently reported temperature-sensitive indocyanine green-loaded pluronic nanocapsules can potentially alleviate this problem. Here we demonstrate a frequency-domain temperature-modulated fluorescence tomography system that could acquire images at high intensity-focused ultrasound resolution with use of these nanocapsules. The system is experimentally verified with a phantom study, where a 3-mm fluorescence object embedded 2 cm deep in a turbid medium is successfully recovered based on both intensity and lifetime contrast.

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عنوان ژورنال:
  • Journal of biomedical optics

دوره 17 5  شماره 

صفحات  -

تاریخ انتشار 2012