اثر ضد التهابی 8 هفته تمرین هوازی بر غلظت پلاسمایی اپلین موش‌های صحرایی نر دیابتی

Background: Recently the role of apelin in inflammation has been known. However, the effect of exercise training-induced cytokine apelin in diabetes status hasn&rsquo;t been investigated. The purpose of this study was to determine the atni-inflammation effect of 8-week aerobic training on apelin plasma concentration in diabetic male rats. Methods: Twenty eight diabetic male Wistar rats were randomly divided into 3 groups: Non-diabetic (n=9), control diabetic (n=9) and trained diabetic (n=10). Type 2 diabetes was induced by intraperitoneal injection of nicotinamide (95 mg/kg body weight) and streptozotocin (60 mg/kg body weight). The training group ran 8-week on treadmill progressively for 45 min at a speed of 24 m/min and a 5% grade. After the training, plasma concentrations of glucose, insulin, TNF-&alpha; and apelin were measured and HOMA-IR was calculated. One-way analysis of variance (ANOVA) and Pearson&rsquo;s correlation was used for analyzing data. P<0.05 was considered to be statistically significant. Results: Results showed a significant decrease in plasma concentrations of glucose, insulin and&nbsp; TNF-&alpha;&nbsp; and HOMA-IR in trained diabetic vs control diabetic group, a significant increase in plasma concentration of apelin in trained diabetic group vs non-diabetic and control diabetic group and a significant negative correlation between plasma concentrations of apelin and TNF-&alpha; in trained diabetic group. Conclusion: It appears that 8-week aerobic training by improvement of insulin sensitivity and decrease of inflammation can increase plasma concentration of apelin in diabetic male rats. &nbsp;