Association between pre-chemotherapy serum levels of vitamin D and clinicopathologic findings in gastric cancer

Authors

  • Ghasem Janbabaei Gastrointestinal cancer research center, Mazandaran University of Medical Sciences, Sari, Iran.
  • Jeyran Mahdavi Izadi Gastrointestinal cancer research center, Mazandaran University of Medical Sciences, Sari, Iran.
  • Omolbanin Amjadi Gastrointestinal cancer research center, Mazandaran University of Medical Sciences, Sari, Iran.
  • Reza Alizadeh-Navaei Gastrointestinal cancer research center, Mazandaran University of Medical Sciences, Sari, Iran.
  • Versa Omrani-Nava Gastrointestinal cancer research center, Mazandaran University of Medical Sciences, Sari, Iran.
Abstract:

Background: To examine serum levels of vitamin D in newly diagnosed gastric cancer (GC) patients compared with normal subjects and any possible association with prognostic variables. Methods: One-hundred subjects (50 GC and 50 controls) were enrolled and serum vitamin D levels were assessed using ELISA. Based on two definitions, vitamin D was classified as a sufficient level (≥30 ng/dL) and optimal level (25-80 ng/dL). The χ2and unpaired t-test was used for data analysis with a significance level of 0.05. Results: The mean serum levels of vitamin D in patients and controls were 26.86 (±14.6) and 31.72 (±13.4), respectively (P=0.09). The prevalence of vitamin D insufficiency and deficiency was higher in GC cases than controls (P=0.045 if sufficient level ≥30 and P=0.065 if sufficient level ≥25). According to histological grade analysis, grade 3 patients (poorly differentiated) were found with significantly lower vitamin D concentrations in serum than grade 1 and 2 subjects (22.25 vs 33.29 ng/dL, P=0.021).  No significant differences were observed between the two groups in Pathological tumor-node-metastasis(pTNM) stages, distant metastasis, and location of the tumor. Conclusion: Higher prevalence of vitamin D insufficiency and deficiency in GC patients may reflect its role in malignancy; however, further studies are needed to confirm this relationship and any possible benefitsto the patients.

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Journal title

volume 11  issue 3

pages  8- 0

publication date 2020-05

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