Association of Helicobacter Pylori Infection with Cardiometabolic Risk Factors among Iranian Adolescents: the CASPIAN III Study

Authors

  • Armita Mahdavi Gorabi Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
  • Behnaz Gharegozlou Dietary Supplements and Probiotics Research Center, Alborz University of Medical Sciences, Karaj, Iran.
  • Enayat Kalantar Dietary Supplements and Probiotics Research Center, Alborz University of Medical Sciences, Karaj, Iran.
  • Hamid Asayesh Department of Medical Emergencies, Qom University of Medical Sciences, Qom, Iran.
  • Mehdi Noroozi Social Determinants of Health Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
  • Mohammand Javad Gharavi Department of Microbiology and Immunology, School of Paramedical Sciences, Iran University of Medical Sciences, Tehran, Iran.
  • Mojgan Oshaghi Dietary Supplements and Probiotics Research Center, Alborz University of Medical Sciences, Karaj, Iran.
  • Mostafa Qorbani Non-communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran & Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
  • Ramin Heshmat Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
  • Roya Kelishadi Department of Pediatrics, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.
  • Shervin Ghaffari Hoseini Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Abstract:

Background: At least half the world’s population is colonized the stomach by Helicobacter pylori (H. pylori) which are a key constituent of the human microbiome. The aim of this study was to investigate the association of cardiometabolic risk factors with H. pylori infection in Iranian adolescents. Materials and Methods: The current study was conducted along with the third survey of a national school-based surveillance system in Iran, entitled "Childhood and Adolescence Surveillance and Prevention of Adult Non-communicable Disease" (CASPIAN) study. Detailed questionnaires on demographic, socioeconomic, dietary, and health-related information of the participants were filled by one of the parents under supervision of trained health-care workers. Trained healthcare professionals measured anthropometric indices, blood pressures according to standard protocols. Fasting venous blood was examined for fasting blood sugar and lipid profile. Results: Overall 882 serum samples were suitable for testing. H. pylori antibody was found in 643 serum samples (72.9%). Among cardiometabolic risk factors, only the mean weight of participants was different between two groups (44.6±11.8 in H. pylori positive and 42.8±11.3 in H. pylori negative group; p=0.04). Overall, 5.1% of adolescents with positive H. pylori tests were overweight or obese, while 1.7% of negative ones were so (p=0.02). In the multivariate regression model, H. pyloriseropositivity increased the risk of overweight (OR, 3.3; 95%CI, 1.2-9.3; p= 0.03). In the multivariate model, association of other cardiometabolic risk factors with H. pylori infection was not statistically significant (p>0.05). Conclusion: Results of present study showed that H. pylori infection was associated with excess weight in adolescents. H. pylori eradication may be decrease the risk of obesity.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

Association of ghrelin with cardiometabolic risk factors in Iranian adolescents: the CASPIAN-III study

Introduction: Current evidence suggests that ghrelin could contribute to the development of metabolic syndrome (MetS) in adults, but limited experience exists in adolescents. This study aims to explore the association of ghrelin levels with the MetS components among Iranian adolescents. Methods: In this case-control study, 32 adolescents with MetS and 148 healthy controls were selected randomly...

full text

Seroprevalence of Helicobacter Pylori Infection in Iranian Adolescents: the CASPIAN- III Study

Background: Helicobacter pylori (H.pylori) is a common bacterial infection, with considerably high morbidity and mortality worldwide. This bacterium represents a key factor in the etiology of various chronic infections ranging from gastritis, peptic ulcer disease to gastric cancer; but the prevalence has large variations in different communities. The aim of this study was to estimate the preval...

full text

seroprevalence of helicobacter pylori infection in iranian adolescents: the caspian- iii study

background: helicobacter pylori (h.pylori) is a common bacterial infection, with considerably high morbidity and mortality worldwide. this bacterium represents a key factor in the etiology of various chronic infections ranging from gastritis, peptic ulcer disease to gastric cancer; but the prevalence has large variations in different communities. the aim of this study was to estimate the preval...

full text

Latent Class Analysis of the cardiometabolic risk factors in children and adolescents: the CASPIAN-V study

Background: Cardio-metabolic syndrome indicates the clustering of several risk factors. The aims of this study were to identify the subgroups of the Iranian children and adolescents on the basis of the components of the cardio-metabolic syndrome and assess the role of demographic characteristics, socioeconomic status and life style related behaviors on the membership of participants in each lat...

full text

screen time and its relation to cardiometabolic risk among children and adolescents: the caspian-iii study

background: among chronic non-communicable diseases (cncds), the occurrence of cardiovascular diseases and diabetes is more prominent. cncds origin in early life; with sedentary habits, notably prolonged screen time (st), leisure time spent on watching tv and working computer, suggested as one of their risk factors. we aimed to investigate the relationship between st and cardiometabolic risk fa...

full text

Generalized or abdominal obesity: which one better identifies cardiometabolic risk factors among children and adolescents? The CASPIAN III study.

OBJECTIVES We investigated the association of generalized and abdominal obesity with cardiometabolic risk factors in children and adolescents. METHODS Data were obtained from a surveillance system entitled CASPIAN-III study in school students aged 10-18 years in Iran. Data of subjects with normal body mass index (BMI) or above (BMI ≥ 5th percentile) were analyzed. The associations of obesity ...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 6  issue 2

pages  7045- 7054

publication date 2018-02-01

By following a journal you will be notified via email when a new issue of this journal is published.

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023