Comparing the Effect of Rosemary and Mefenamic Acid Capsules on Symptoms of Primary Dysmenorrhea: A Randomized Double-blind Trial

Authors

  • Abedian, Zahra MidwiferyInstructor, Department of Midwifery, Faculty of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran
  • Emami, Seyed Ahmad Professor, Department of Pharmacognosy, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
  • Esmaily, Habibollah Professor, Department of Biostatistics and Epidemiology, Health Sciences Research Center, Faculty of Health, Mashhad University of Medical Sciences, Mashhad, Iran
Abstract:

  Background and purpose: Dysmenorrhea is associated with one or more systemic symptoms, including nausea and vomiting, fatigue, diarrhea, low back pain, and headache in more than 50% of the cases. These symptoms disrupt social communication in affected women. This investigation was conducted to compare the effect of rosemary and mefenamic acid oral capsules on the symptoms of primary dysmenorrhea. Materials and methods: This randomized double-blind trial was conducted in 82 students with primary dysmenorrhea in Islamic Azad University of Mashhad, Iran. Participants were studied in two cycles for the symptoms of dysmenorrhea. They were randomly assigned into two groups; rosemary (n=45) and mefenamic acid (n=45) using PASS software. They received 250 mg of medications in the first three menstruation days 8-hourly. The visual analogue scale was used to determine the severity of pain. Data were analyzed in SPSS V24. Results: The mean scores for pain intensity significantly reduced in rosemary group and mefenamic acid group compared to baseline scores (16.81±10.96 and 18.45±12.80, respectively) (P<0.001). But, there were no significant differences between the two groups (P>0.05). Some symptoms, including nausea in first cycle (P=0.01) and second cycle (P=0.02) and boredom in first cycle (P=0.02) and second cycle (P=0.01) were found to be significantly different between the two groups. But, other symptoms were not significantly different between the two groups (P>0.05). Conclusion: Pain reducing effects of rosemary were similar to those of mefenamic acid and it also reduced boredom and nausea. Medicinal drugs cause fewer side effects, therefore, rosemary could be used as an alternative to mefenamic acid in management of dysmenorrhea.   (Clinical Trials Registry Number: IRCT2016062228586N1)

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

The Effect of Mefenamic Acid and Melissa officinalis on Primary Dysmenorrhea: A Randomized Clinical Trial Study

Background and aim: Melissa officinalis was traditionally used for pain relief and treatment of some diseases. The aim of the study was to compare the effect of mefenamic acid and Melissa officinalis (Melissa) on pain management in primary dysmenorrhea. Methods: In this clinical trial, fortythree eligible women with moderate to severe primary dysmenorrhea were randomly allocated into the Meliss...

full text

The Effect of Hydroxychloroquine on Symptoms of Knee Osteoarthritis: A Double-Blind Randomized Controlled Clinical Trial

Background: Osteoarthritis is a degenerative joint disorder of articular cartilage and is the most common type of arthritis in the elderly. There are only a few reports regarding the use of Hydroxychloroquine in the treatment of osteoarthritis. Methods: To investigate the effects of Hydroxychloroquine on the symptoms of mild to moderate knee osteoarthritis (Kellgren and Lawrence grade II and II...

full text

The Positive Effects of Zinc Supplements on the Improvement of Primary Dysmenorrhea and Premenstrual Symptoms: A Double-blind, Randomized, Controlled Trial

Background & aim:Primary dysmenorrhea can be relieved via some medical and non-medical approaches. In this regard, the probable therapeutic role of zinc supplements has been recently emphasized. The present study was conducted to determine the positive effects of zinc supplements on relieving primary dysmenorrhea and premenstrual symptoms. Methods:The present double-blind, randomized, controlle...

full text

Effect of Dill (Anethum graveolens) on the severity of primary dysmenorrhea in compared with mefenamic acid: A randomized, double-blind trial

BACKGROUND Dysmenorrhea has negative effects on women's life. Due to side-effects of chemical drugs, there is growing trend toward herbal medicine. The aim of this study was to assess the effect of Dill compared to mefenamic acid on primary dysmenorrhea. MATERIALS AND METHODS This double-blind, randomized, clinical trial study was conducted on 75 single female students between 18 and 28 years...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 30  issue 188

pages  40- 52

publication date 2020-09

By following a journal you will be notified via email when a new issue of this journal is published.

Keywords

No Keywords

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023