Effect of levamisole on treatment of recurrent aphthous stomatitis: A systematic review and meta-analysis

Authors

  • Elham Abbaszadeh Resident, Department of Oral Medicine and Orofacial Pain, School of Dentistry, Kerman University of Medical Sciences, ‎Kerman, Iran
  • Goli Chamani Associate Professor, Department of Oral Medicine and Orofacial Pain, School of Dentistry, Kerman University of Medical ‎Sciences, Kerman, Iran
  • Maryam Rad Oral and Dental Diseases Research Center AND Kerman Social Determinants on Oral Health Research ‎Center, Kerman ‎University of Medical Sciences, Kerman, Iran
  • Masoumeh Sadeghi PhD Candidate, Department of Epidemiology, School of Public Health, Shahid Beheshti University of Medical Sciences, ‎Tehran, Iran
  • Mohammad Reza Zarei Associate Professor, Department of Oral Medicine and Orofacial Pain, School of Dentistry, Kerman University of Medical ‎Sciences, Kerman, Iran
  • Seyyed Reza Hashemimanesh Dentist, Private Practice, Kerman, Iran
Abstract:

BACKGROUND AND AIM: The aim of this study was to systematically analyze the effect of levamisole on treatment of recurrent aphthous stomatitis (RAS).METHODS: An electronic search was executed in PubMed, Cochrane, and Scopus after determining the research question using the appropriate Medical Subject Heading (MeSH) term covering the period from 1975 to 2015. Additional publications from hand searching and the reference section of each relevant article enriched the article list. Finally, 9 articles that have assessed the effect of levamisole on the treatment of RAS and had suitable qualifications for the accomplishment of systematic review and meta-analysis were included.RESULTS: The results showed that the chance of improvement in patients taking levamisole was 6 [odds ratio (OR) = 5.67, 95% confidence interval (CI)] times more than in patients not taking this drug.CONCLUSION: It appears that levamisole is an effective drug for the treatment of RAS, but further appropriate studies should carryout in this context.

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Journal title

volume 5  issue 2

pages  70- 77

publication date 2016-05-28

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