Insulin resistance and adverse metabolic profile in overweight/obese and normal weight of young women with polycystic ovary syndrome

Authors

  • Azita Ghanbarpour Clinical Research Development unit of Ayatollah Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran
  • Maryam Gholinezhad Infertility and Reproductive Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
  • Masoumeh Golsorkhtabaramiri Infertility and Reproductive Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
  • Sedighe Esmaeilzadeh Infertility and Reproductive Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
Abstract:

Background: Polycystic ovary syndrome (PCOs) is an endocrine-metabolic disorder. This study intends to determine the comparison of insulin resistance (IR) and metabolic disturbance in overweight/obese and normal-weight of young women with polycystic ovary syndrome. Methods: Using a comparative cross-sectional study design in 2015, 27 normal weight (183.15) vs. 8.3% (5) in the normal group (P<0.001). 82.4% (62) of the overweight/obese group revealed low insulin sensitivity (QUICKI<0.34) while this value was 17.6 % (13) within their lean counterparts (p<0.001). In the study group, 89.7 % (54) showed elevated fasting insulin concentration (>13&micro;U/ml) vs. 10.3% (7) in the control group (p<0.001). Conclusions: Overweight/obese PCOs patients revealed higher insulin resistance and lower insulin sensitivity, and also greater TG and LDL cholesterol. Priority of management of insulin resistance and lipid profile should be considered on identifying these potentially major complications.</bmi &nbsp;

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Journal title

volume 9  issue None

pages  260- 267

publication date 2018-05

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