Loading Drug on Nanostructured Ti6Al4V-HA for Implant Applications

Authors

S.K. Sadrnezhaad New materials, Materials and Energy research center

Somaya Abbaspour Department of Materials Science and Engineering, Sharif University of Technology

Abstract:

Arrayed Ti6Al4V nanotubes (TNT) coated with hydroxyapatite (HA) were synthesized via electrochemical anodization method. Paracetamol was loaded onto TNT-HA electrode. Effects of anodization, nanotube formation and hydroxyapatite deposition on sorption and release of the drug were investigated. Saturation time of paracetamol on the anodized samples was 30% shorter than the hydroxyapatite-coated samples. Release behavior of the loaded drug was studied by (a) plunging the probe into phosphate buffered saline (PBS), (b) sampling the drug-loaded PBS at different times and (c) analyzing the solution via ultraviolet-visible (UV-vis) spectroscopy. Results showed that HA electrodes hold higher amounts of paracetamol than the anodized samples at longer times. Scanning electron microscopy (SEM), MTT assay, and nanoindentation tests were used to characterize the produced electrodes.

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Journal title

International Journal of Engineering

volume 31 issue 8

pages 1159- 1165

publication date 2018-08-01

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Keywords

Titanium nanotubes Drug capacity Drug release Hydroxyapatite Paracetamol

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