Negative Correlation between Serum S100B and Leptin Levels in Schizophrenic Patients During Treatment with Clozapine and Risperidone: Preliminary Evidence

Authors

  • Adeleh Sahebnasagh Department of Pharmacotherapy, faculty of Pharmacy, Mazandaran University of Medical Science and Health Services, Sari, Iran
  • Fatemeh Barari Pharm. D, Mazandaran University of Medical Science and Health Services ,Sari, Iran
  • Narjes Hendoiee Department of Pharmacotherapy, Faculty of Pharmacy and Psychiatry and Behavioral Sciences Research Center,Mazandaran University of Medical Science and Health Services , Mazandarn , Iran.
  • Seyed Hamzeh Hosseini Professor of Psychiatry, Psychiatry and Behavioral Sciences Research Center, Mazandarn University of Medical Sciences and Health Services. Imam hospital, Sari, Mazandarn , Iran
  • Shahram Ala Department of Pharmacotherapy, Faculty of Pharmacy, Mazandaran University Medical Sciences, Sari, Mazandaran, Iran
  • Zahra Khazaeipour Brain and Spinal Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
Abstract:

Recently, extensive efforts have been made to understand the rate of energy expenditure and the weight gain associated with atypical antipsychotic treatment, including identification of markers of obesity risk. In recent years, leptin, an adipocyte hormone, has gained significant interest in psychiatric disorders. S100B has been considered as a surrogate marker for astrocyte-specific damage in neurologic disorders. Also, S100B has been detected in adipose with concentration as high as nervous tissue as a second release source. In this study we evaluated the relationship between S100B and leptin in schizophrenic patients under treatment with clozapine and risperidone.This study included 19 patients meeting the DSM-IV-TR criteria for schizophrenia, having body mass index (BMI) of 16- 25 kg/m2 and suffering schizophrenia for more than 3 years and from this study. Twenty five healthy controls were group matched for age and gender whose BMI was 16-25 kg/m2. Serum S100B and leptin levels and positive and negative symptom scale (PANSS) were assessed at admission and after six weeks. During the study, S100B showed a strong and negative correlation with leptin (r = -0.5, P = 0.01). Also, there were negative correlation between serum S100B level and PANSS negative subscale after 6 weeks of treatment (r  = -0.048, P = 0.8). Positive correlation between leptin level and PANSS suggested a potential role for leptin which can mediate the link between antipsychotic induced weight gain and therapeutic response in schizophrenia.  

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

negative correlation between serum s100b and leptin levels in schizophrenic patients during treatment with clozapine and risperidone: preliminary evidence

recently, extensive efforts have been made to understand the rate of energy expenditure and the weight gain associated with atypical antipsychotic treatment, including identification of markers of obesity risk. in recent years, leptin, an adipocyte hormone, has gained significant interest in psychiatric disorders. s100b has been considered as a surrogate marker for astrocyte-specific damage in ...

full text

Serum TNF-α, IL-10 and IL-2 in Schizophrenic Patients Before and After Treatment with Risperidone and Clozapine

Background: Schizophrenia is a disorder of the executive function of both sensory and central nervous system. Recent studies suggest that immune mechanisms play a role in the pathophysiology of this disease. The variations in cytokine concentrations have been associated with psychopathology and treatment of schizophrenia. Objective: To investigate the changes in serum concentrations of TNF- α, ...

full text

serum tnf-α, il-10 and il-2 in schizophrenic patients before and after treatment with risperidone and clozapine

background: schizophrenia is a disorder of the executive function of both sensory and central nervous system. recent studies suggest that immune mechanisms play a role in the pathophysiology of this disease. the variations in cytokine concentrations have been associated with psychopathology and treatment of schizophrenia. objective: to investigate the changes in serum concentrations of tnf- α, ...

full text

Serum TNF-α, IL-10 and IL-2 in schizophrenic patients before and after treatment with risperidone and clozapine.

BACKGROUND Schizophrenia is a disorder of the executive function of both sensory and central nervous system. Recent studies suggest that immune mechanisms play a role in the pathophysiology of this disease. The variations in cytokine concentrations have been associated with psychopathology and treatment of schizophrenia. OBJECTIVE To investigate the changes in serum concentrations of TNF-α, I...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 15  issue 1

pages  323- 330

publication date 2016-02-01

By following a journal you will be notified via email when a new issue of this journal is published.

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023