The effect of iron supplement on children with euthyroid goiter: a randomized placebo-controlled clinical trial

Authors

  • F Shamsi
  • M Akbarzadeh
  • M Ordooei
  • R Masoumi Dehshiri
  • R Soleimanizad
Abstract:

Background Endemic goiter is present in most parts of Iran. Iron deficiency adversely affects the physiology of thyroid. The initial steps of thyroid hormone synthesis are catalyzed by thyroperoxidases and are dependent on iron. In many developing countries, children are at high risk of both goiter and iron deficiency anemia. In addition, iron deficiency may alter central nervous system control of thyroid metabolism andalso Iron-deficiency anemia decreases plasma concentrations of thyroxine and triiodothyronine. Material and method We conducted a randomized, double-blind,controlled trial in 2-12-y-old children with euthyroid goiter and without iron-deficiency anemia. The children weredivided into two groups: The Patients who were under treatment with ferrous-sulphat and controls .active treatment consisted of iron supplementation was administered orally with a dose of 2 mg/kg day. The duration of active treatment was 12 weeks. Results In this study 40 children (female: 22, male: 18) were divided into two groups randomly. (20 patients in each group).There were no significant differences at baselines between groups with regard to gender, age and weigh. At the end of the study, the reduction of more than one grade of goiter was significant between iron-treated and placebo groups. In treatment group, 16 patients (80%) had decreased grade of goiter, while in the control group, 3 patients (15%) had grade reduction(P-value<0.001). Conclusion At the end of the study, decrease of more than one grade of goiter had significant differences between iron-treated and control groups.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

the effect of iron supplement on children with euthyroid goiter: a randomized placebo-controlled clinical trial

background endemic goiter is present in most parts of iran. iron deficiency adversely affects the physiology of thyroid. the initial steps of thyroid hormone synthesis are catalyzed by thyroperoxidases and are dependent on iron. in many developing countries, children are at high risk of both goiter and iron deficiency anemia. in addition, iron deficiency may alter central nervous system control...

full text

The effect of iron supplement on children with euthyroid goiter: a randomized placebo-controlled clinical trial

BACKGROUND Endemic goiter is present in most parts of Iran. Iron deficiency adversely affects the physiology of thyroid. The initial steps of thyroid hormone synthesis are catalyzed by thyroperoxidases and are dependent on iron. In many developing countries, children are at high risk of both goiter and iron deficiency anemia. In addition, iron deficiency may alter central nervous system control...

full text

The Effect of Spirulina on Anxiety in Patients with Hypertension: A Randomized Triple-Blind Placebo-Controlled Clinical Trial

Background: High blood pressure, coronary heart disease (CHD), and anxiety ailments entirely lead to many illness in patients and impose expenses on the health care system. Anxiety can significantly predict future CHD consequences. Spirulina is a known antioxidant that has a role in anxiety. The hypothesis was that Spirulina could alleviate anxiety and positively affect hypertension and its con...

full text

The impacts of inhalation aromatherapy with lavender essential oil on students’ test anxiety: a randomized placebo-controlled clinical trial

Background: Test anxiety (TA) can hinder students’ academic achievement and cause them educational decline and psychological problems. Objective: The effect of inhalation aromatherapy with lavender essential oil on nursing students’ test anxiety was investigated. Methods: This was a quasi-experimental study was conducted on 33 nursing students who had taken the Community Health Nursing II cours...

full text

The Effect of Hydroxychloroquine on Symptoms of Knee Osteoarthritis: A Double-Blind Randomized Controlled Clinical Trial

Background: Osteoarthritis is a degenerative joint disorder of articular cartilage and is the most common type of arthritis in the elderly. There are only a few reports regarding the use of Hydroxychloroquine in the treatment of osteoarthritis. Methods: To investigate the effects of Hydroxychloroquine on the symptoms of mild to moderate knee osteoarthritis (Kellgren and Lawrence grade II and II...

full text

Effect of chamomile on chemotherapy-induced neutropenia in pediatric leukemia patients: A randomized triple-blind placebo-controlled clinical trial

Objective: Chemotherapy-induced neutropenia is one of the main side effects of acute lymphoblastic leukemia (ALL) treatment. In this trial, we evaluated the efficacy of chamomile in management of neutropenia.   Materials and Methods: This randomized triple-blind placebo-controlled clinical trial was carried out in 2-18-year-old children with ALL. Particip...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 4  issue 3

pages  84- 88

publication date 2014-09

By following a journal you will be notified via email when a new issue of this journal is published.

Keywords

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023