The effect of Vitamin B6 on chemotherapy induced nausea and vomiting in pediatric cancer

Authors

  • Aigin Eghbali Students Research Committee, school of medicine, Iran university of Medical Sciences, Tehran, Iran
  • Arefeh Adelnia Student Research Committee, Arak University of Medical Sciences, Arak, Iran
  • Aziz Eghbali Clinical Research Development Center of Amirkabir Hospital, Arak University of Medical Sciences, Arak, Iran
  • Golrokh Farokhmehr Veterinary Student, Faculty of Veterinary Medicine, Islamic Azad University, Urmia, Iran.
  • Sarvenaz Mehrabi , Student Research Committee, Arak University of Medical Sciences, Arak, Iran
  • Siam Zahedi Student Research Committee, Arak University of Medical Sciences, Arak, Iran
Abstract:

Background: Nausea and vomiting are the common side-effects of chemotherapy in children with malignancy. In this study, the effectiveness of vitamin B6 in reducing the chemo-induced nausea and vomiting (CINV) in children was tested. Material and methods: A triple-blind clinical trials was performed on 100 children with malignancy referring to the pediatric clinic of Amir Kabir Hospital, Arak, Iran. Besides the infusion of granisetron (3mg/3ml) half an hour before each chemotherapy cycle, an intravenous dose of vitamin B6 (100 mg for children from 2 to 5 years old, 200 mg for children from 5 to 10 years old, and 300 mg for children older than 10) was given 6 hours before the first chemotherapy cycle and placebo was injected (2-5 years old: 100 mg, 5-10 years old: 200 mg, age≥ 10 years old: 300mg) 6 hours before the second cycle. Then the severity of nausea and the frequency of vomiting episodes in each cycle were recorded to be compared.  Results: The mean age of children was 7.98 ± 3.133 years old. The most common and rare malignancy were acute lymphocytic leukemia (ALL) (46%) and ependymoma (0.5%), respectively. Vincristin was the most commonly used chemotherapy agent (28%). A positive correlation between the severity of nausea(R=0.313, P-value=0.0016) and frequency of vomiting with age was found (R=0.319, P-value=0.0012). However, no noticeable association was observed between N/V and gender (P-value.0.05). There was a considerable correlation between the frequency of vomiting and different tumor types in this study (P-value=0.0006).In comparison with placebo, Vitamin B6 significantly reduced the severity of nausea (P = 0.0001) as well as the frequency of vomiting (P-value = 0.0005). It was also more effective in ALL compared to rhabdomyosarcoma (P-value=0.001). Conclusion: This study suggested that vitamin B6 can be considered as an appropriate alternative to treat CINV in children with malignancy.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

the effect of massage therapy on chemotherapy-induced nausea and vomiting in pediatric cancer

background: nausea and vomiting are the most common and unpleasant side effects of chemotherapy, and they may prevent successful treatment completion. antiemetics not only cannot control nausea and vomiting completely but also have numerous side effects. so it is necessary to find other methods for a better control. this study aimed to assess the effect of massage therapy on chemotherapy-induce...

full text

The Effect of Group Behavioral Activation Therapy on Chemotherapy - induced Nausea and Vomiting among Women with Breast Cancer

Background and Aim: Nausea and vomiting are one of the most common and worst side effects of chemotherapy in breast cancer patient and and despite the advances in medical science, Chemotherapy Induced Nausea and Vomiting is still a challenge to control.The aim of this study was to investigate the effect of group behavioral activation therapy on Chemotherapy Induced Nausea and Vomiting among wom...

full text

the effect of aqueous extract of garlic on formalin-induced pain in male rats

چکیده اثر عصاره آبی سیر بر درد ناشی از آزمون فرمالین در موش صحرایی نر به کوشش نرگس اسکندری روزبهانی زمینه و هدف: گیاه سیر از خانواده لیلیاسه و گونهallium sativum بومی آسیای میانه بوده و از دوران ،باستان تاکنون به خواص درمانی متفاوت آن مثل: کاهندگی قندخون، کلسترول خون، فشار خون، اثرات مفیدآن بر دستگاه قلبی عروقی و بیماریهای انعقادی خون، اثرات آنتی اکسیداتیو، درمان بیماریهای تنفسی وگوارشی، ا...

15 صفحه اول

Chemotherapy-induced nausea and vomiting.

younger patient age, platinumor anthracyclinebased chemotherapy, low alcohol consumption, earlier cycles of chemotherapy, previous history of morning sickness, and prior emetic episodes after chemotherapy. The acute and delayed scoring systems both had good predictive accuracy when applied to the external validation sample (acute— auroc: 0.69; 95% confidence interval: 0.59 to 0.79; delayed—auro...

full text

The Role of Clinical Guidelines for the Management of Chemotherapy-Induced Nausea and Vomiting in Children with Cancer

Background: Nausea and vomiting are among the most important side-effects associated with chemotherapy in children with cancer, affecting the quality of their lives. Clinical guidelines for selecting antiemetics are effective in reducing acute chemotherapy-induced nausea and vomiting (CINV). Materials and Methods: The present quasi-experimental study compared the effectiveness of the Pediatric...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 10  issue 1

pages  1- 9

publication date 2020-01

By following a journal you will be notified via email when a new issue of this journal is published.

Keywords

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023