The Relation between Left Ventricular Function and Serum Ferritin in Major Β-Thalassemia

Authors

  • Atefeh Dehghani
  • Azam Sadat Hashemi
  • Farideh Zaolfaghari
  • Mahvash Akhavane ghalibaf
  • Mohsen beigomi
  • Seid Mostafa Behjati
  • Sima Montazare Lotfe Elahi
Abstract:

Abstract Objective Cardiac dysfunction is a major cause of death in patients with beta thalassemia. In these patients, repeated blood transfusion, ineffective erythropoiesis and increased gastrointestinal iron absorption lead to iron overload in the body and this induced heart failure. Left ventricular ejection fraction was measured in major beta thalassemia (β-Th) patients to detect the relation of serum ferritin level and left ventricular systolic function. Materials and Methods The present prospective study evaluated 75 patients with β-thalassemia (39 female, 36 male) aged one to 44 years old. They were treated with desferal 5 days a week for at least six months. For this study they treated by desferal 7 days a week. Left ventricular ejection fraction and serum ferritin were measured before and after intervention, and they were compared for the best treatment. Results The mean ejection fraction was 60.45% and 62.9% before and after aggressive therapy, which difference was significant. Serum ferritin level also was reduced after intervention. Difference between mean ferritin before and after intervention was 49.984. Serum ferritin showed negative correlation with left ventricular function. Conclusion Lower serum ferritin concentration with aggressive therapy was associated with better left ventricular function.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

the relation between left ventricular function and serum ferritin in major β-thalassemia

abstract objective cardiac dysfunction is a major cause of death in patients with beta thalassemia. in these patients, repeated blood transfusion, ineffective erythropoiesis and increased gastrointestinal iron absorption lead to iron overload in the body and this induced heart failure. left ventricular ejection fraction was measured in major beta thalassemia (β-th) patients to detect the relati...

full text

Association between serum ferritin level and diastolic cardiac function in patients with major β-thalassemia

Abstract Background Prevention of myocardial siderosis is a key step to reduce rate of mortality in thalassemic patients. Our objective was to study association between echocardiography parameters and serum ferritin level in patients with major thalassemia. Materials and Methods Sixty-six patients with major thalassemia were studied in Amir Kabir hospital, Arak, Iran. Serum ferritin levels ...

full text

The relation between left ventricular diastolic indices and serum ferritin in thalassemia major.

Iron-induced heart failure is the primary cause of death in thalassemia major patients who receive continuous transfusions. Recent studies have suggested that diastolic function is impaired prior to systolic function in process of hemochromatosis, but they did not come to agreement on the first impaired diastolic index. Additionally, serum ferritin concentration is not a reliable indicator of b...

full text

Evaluation of the Relationship between Serum Ferritin Level and Renal Function in Patients with Thalassemia Major

Background and Aim: Serum ferritin in patients with thalassemia major is an indicator of iron overload, which is the main cause of damage to various organs of the body in patients with thalassemia major. The aim of this study was to investigate the relationship between serum ferritin level and renal function in thalassemia major patients. Materials and Methods: This descriptive and cross-sectio...

full text

LEFT VENTRICULAR DIASTOLIC ABNORMALITIES IN β-THALASSEMIA MAJOR WITH NORMAL SYSTOLIC FUNCTION

In order to identify left ventricular diastolic function in patients with betathalassemia major and normal systolic function by noninvasive M-mode and Doppler echocardiography, an analytic study was designed in a university hospital in Sari. We have studied 44 patients (23 men and 21 women), mean age 15.48±2.16 (range 12 to 20) and 43 age and sex matched control subjects. Peak flow velocit...

full text

Correlation of Serum Ferritin Level with Cardiac Function in β-Thalassemia Major

Background: The most important problem in regular transfusion dependent β-thalassemia major is cardiac dysfunction due to iron deposition in it. The aim of this study was to evaluate correlation between serum ferritin levels and cardiac function in β-thalassemia major in Mofid Hospital. Materials and Methods: There were 112 β-thalassemia patients with a mean age of 13.55± 6.12 years, of whom 49...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 1  issue 3

pages  94- 97

publication date 2011-09

By following a journal you will be notified via email when a new issue of this journal is published.

Keywords

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023