سعید سمنانیان
استاد، گروه فیزیولوژی، دانشکده علوم پزشکی، دانشگاه تربیت مدرس، تهران، ایران
[ 1 ] - اثر مهاری اورکسین A بر انتقالات سیناپسی گابائرژیک نورون‌های هسته‌ی لوکوس‌سرولئوس در موش صحرایی
سابقه و هدف:هستة لوکوس‌سرولئوس حاوی دسته‌های بزرگی از نورون‌های نورآدرنرژیک است که ارتباط گسترده‌ای با دیگر نواحی سیستم عصبی مرکزی از جمله هیپوتالاموس دارد. این هسته در تنظیم فرایندهای شناختی شامل توجه، یادگیری، حافظه و وابستگی به اوپیات‌ها نقش ایفا می‌کند. هر چند اثر تحریکی اورکسین A بر نورون‌های هستة لوکوس‌سرولئوس نشان داده شده است، اثر آن بر انتقالات مهاری سیناپسی نورون‌های این هسته ناشناخته...
[ 2 ] - In Vitro Differentiation of Neural Stem Cells into Noradrenergic-Like Cells
Neural stem cells (NSCs) as a heterogeneous multipotent and self- renewal population are found in different areas in the developing mammalian nervous system, as well as the sub-ventricular zone (SVZ) and the hippocampus of the adult brain. NSCs can give rise to neurons, astrocytes and oligodendrocytes. The aim of this study was to differentiate neural stem cells into noradrenergic–like cells in...
[ 3 ] - Effect of repeated transcranial magnetic stimulation during epileptogenesis on spontaneous activity of hippocampal CA1 pyramidal neurons in rats
Introduction: Considering the antiepileptogenic effects of repeated transcranial magnetic stimulation (rTMS), the effect of rTMS applied during amygdala kindling on spontaneous activity of hippocampal CA1 pyramidal neurons was investigated. Materials and Methods: A tripolar electrode was inserted in basolateral amygdala of Male Wistar rats. After a recovery period, animals received daily kindl...
[ 4 ] - Effects of bilateral lesion of the locus coeruleus on the sleep-wake cycle in the rat
Introduction: Noradrenergic cells in LC participate in the process of cortical activation and behavioral arousal. The evidence suggests that locus ceoruleus (LC) plays an important role in the sleep-wake cycle. The aim of this study was stereological estimation of cavity caused by lesion and assessment of sleep stages after bilateral lesion of the LC. Materials and Methods: Male Wistar rats we...
[ 5 ] - Microinjection of orexin-A into the locus coeruleus area induces morphine withdrawal-like behaviors in morphine dependent rats
Introduction: It has been shown that orexin peptides have a role in opioid withdrawal behaviors. Orexin-expressing neurons that are present in the hypothalamic nuclei send dense projections to the Locus Coeruleus (LC). Withdrawal syndrome is temporally associated with hyperactivity of LC neurons. However, LC neurons do not show withdrawalinduced hyperactivity in the brain slices from morphin...
[ 6 ] - Role of Orexin-A receptors within the Locus Coeruleus in the antinociception induced by microinjection of carbachol into the lateral hypothalamus
Introduction: Previous studies have shown that stimulation of lateral hypothalamus (LH) produces antinociception. Orexin-A (OXA) receptor is strongly expressed in the nucleus locus coeruleus (LC) and orexinergic fibers densely project from LH to LC. In this study, we assessed the role of LC and its OXA receptors in antinociceptive response induced by LH chemical stimulation in the rat. Meth...
[ 7 ] - Postnatal developmental alterations in the locus coeruleus neuronal fast excitatory postsynaptic currents mediated by ionotropic glutamate receptors of rat
Introduction: In the present work, spontaneous postsynaptic currents were assessed to investigate the postnatal development of excitatory postsynaptic currents in locus coeruleus neurons. Methods: In this study, AMPA and NMDA receptor-mediated spontaneous synaptic currents in the neurons of locus coeruleus were assessed using whole cell voltage-clamp recording during the first three weeks. ...
[ 8 ] - Microinfusion of TNFα and its antibody into locus coeruleus modifies nerve injury induced thermal hyperalgesia and mechanical allodynia
Introduction: Glial activation and secretion of cytokines at the spinal level is known as part of chronic pain pathogenesis. Although changes in TNFα at the supraspinal level are reported during chronic pain, its exact role and site of action remain to be elucidated. We investigated the effect of microinfusion of TNFα into the LC in a rat model of neuropathic pain. Methods: Male Wistar rats...
[ 9 ] - Is the pain modulatory action of 17β-estradiol in locus coeruleus of male rats is mediated by GABAA receptors?
Introduction: Estradiol is a neuroactive steroid, which is found in several brain areas such as locus coeruleus (LC). Estradiol modulates nociception by binding to its receptors and also by allosteric interaction with other membranebound receptors like glutamate and GABAA receptors. LC is involved in noradrenergic descending pain modulation. Methods: In order to study the effect of 17β-estra...
[ 10 ] - Effect of chronic morphine administration on Ca2+/Calmodulin-Dependent protein kinase IIα activity in rat locus coeruleus and its possible role in morphine dependency
Introduction: The aim of this study was to assess the effect of Ca2+/calmodulin-dependent kinase IIα (CaMKIIα) inhibitor (KN-93) injection into the locus coeruleus (LC) on the modulation of withdrawal signs. We also sought to study the effect of chronic morphine administration on CaMKIIα activity in the rat LC. Methods: The research was based on behavioral and molecular studies. In the behav...
[ 11 ] - Role of matrix metalloproteinase II on analgesic effect of nitric oxide inhibition in rat
Abstract Introduction: Matrix metalloproteinase 2 is one of the inflammatory mediators that is involved in nociceptive processing and its production is regulated by many inflammatory factors such as nitric oxide. We studied the role of MMP-2 on the analgesic effects of nNOS inhibitor. Methods: Considering that nitric oxide has many roles in pain processing, we studied the CSF levels of MMP-2 ...
[ 12 ] - Hypothalamus Pituitary Adrenal axis and stimulatory G proteins signaling role in nociceptive changes induced by forced swim stress
Introduction: Different mechanisms are involved in stress induced analgesia (SIA) and hyperalgesia (SIH). Repeated stress induces development of tolerance to SIA. The role of HPA axis and Gs signaling pathway in these effects are investigated in the current study. Methods: Forced swim stress (5 min/day) in water (20±1 ºC) was employed to adult male Wistar rats (200-250 g). The nociceptive t...
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