بررسی ارتباط بین آلل HLA-DQA2 با بیماری آلوپسیا آره آتا
نویسندگان
چکیده مقاله:
Background and purpose: Alopecia areata (AA), also known as spot baldness, is an autoimmune disease in which hair is lost from some or all areas of the body. Genetic factors are known to play a role in the onset of this disease. The HLA complex genes are primarily involved in AA. In present study, effect of HLA-DQA2 allele frequency was analyzed in Iranian AA patients and control samples. Materials and methods: The study group comprised 30 patients with Alopecia areata and 15 healthy controls. Genomic DNA was extracted from whole blood using DNG plus method. Polymerase chain reaction with sequence specific primers technique (PCR-SSP) was performed to detect HLA-DQA2. The association between HLA-DQA2 allele and some risk factors such as family history, anemia, and the onset of the disease was analyzed. Results: Patients included 13 females and 17 males (mean age 26.3 ±12.5 years) and the controls were five females and 10 males (mean age 30.1±5.8 years). The frequency of HLA-DQA2 allele in AA patients (93.33%) was not significant compared to that of the controls (76.66%) (OR 0.94, 95% CI =0.018-1.018, p>0.05). No association was found between the disease and family history of AA (OR=0.09; 95% CI=0.01-0.119, P= 0), and onset of disease (OR =1.015; 95% CI=0.95-1.07, p=0.607). But significant correlation was observed between AA disease and anemia (OR =0.017; 95% CI=0.02-0.179, p=0.001). Conclusion: This study did not show strong correlation between HLA-DQA2 allele and developing Alopecia areata. The HLA-DQA2 allele was associated with anemia, but not related to family history and the onset of disease.
منابع مشابه
بررسی الل HLA-DQB1*3 در بیماران مبتلا به آلوپسیا آره آتا
Background and Objective: Alopecia Areata (AA) is a multifactorial disease characterized by hair loss especially from the scalp affecting approximately 5.3 million people. Since major histocompatibility complex (HLA) region is considered to be associated with AA susceptibility, the effect of HLA-DQB1*3 allele frequency was investigated in the present study in AA patients and their respective co...
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Introduction & Objective: Alopecia areata is the most common skin disease that presents as areas without hair and may affect any hair bearing area of body. Different reports about ocular alterations in patients with alopecia areata are presented. The aim of this study was to evaluate the ocular alterations in patients with this disease. Material & Methods: In this descriptive - analytic study, ...
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Background and Objective: Alopecia Areata (AA) is characterized by an autoimmune hair loss usually, but not limited to, the scalp, affecting approximately 1-2% of the general population. Although the etiology and pathogenesis of this disease is still unknown, it is known that TNFα-308G/A polymorphism can influence the development of AA. The aim of this study was to investigate TNF-α(rs1800629) ...
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مقدمه و هدف: آلوپسی آره آتا از جمله شایعترین بیماریهای پوستی است که بصورت مناطق فاقد مو، هر سطح مودار بدن را ممکن است درگیر کند. گزارشات مختلفی درمورد تغییرات چشمی در این بیماران ارائه شده است. هدف از مطالعه حاضر تعیین تغییرات چشمی در بیماران مبتلا به این بیماری است. روش کار: در این مطالعه توصیفی- تحلیلی، 251 بیمار مبتلا به آلوپسی آره آتا مورد مطالعه قرار گرفتند. خصوصیات و سوابق این بیماران شام...
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عنوان ژورنال
دوره 28 شماره 168
صفحات 22- 28
تاریخ انتشار 2019-01
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