بررسی مقاومت انسولینی در افراد چاق و بروز اجزاء سندروم X

Background and purpose: 33% of population in the developing countries are obese. Ïn spite of side effects such as osteo arthritis, gall stone, and probably some cancers, and metabolic disorders which are collectively known as X syndrome is associated with hyperlipidosis, hypertension, hyperuremia diabetes mellitus and ischemia, each of these factors alone can lead to complications or mortality in the obeses. Since there is less studies regarding insuline resistance in obeses in our country we conducted a research in this regard. Hypertension due to insuline resistance can express the association of these metabolic disorders. Materials and Methods: Totally, 56 males and females divided in 4 groups of obeses are thin on the basis of their body mass index were collected. This study was a case control method. Fasting serum samples were drained to assay insuline, sugar, uric acid and lipid. The blood pressure was twice in fasting condition. The obtained data were analyzed by students non paired t-test. Results: Fasting serum insuline level in obese was 5.4 ± 6.5 µl/ml and in thin 2.2 ± 1.2 µl/ml (P<0.02). Systolic blood pressure in obese was 123.8 ± 12.8 mm/Hg and in thin 115.3±8.3 mm/Hg (P<0.01). Diastolic blood pressure in obse was 81.44±9.5 mm/Hg and in thin 74±7 mm/Hg (P<0.01). there was significant difference in all the three criteria. Serum sugar, Üric acid and lipids did not show significant differences. Çonclusion: This study showed hyperinsulinism (insuline resistance) in obeses, same as primary studies on obeses. Systolic and diastolic blood pressure as a X syndrome fraction was more in obeses than the thin. But is not defined in hypertension.