تاثیر تمرین در آب بر پاسخ های ایمنی پروتئین های CRP و کمپلمان C3 و C4 در بیماران آرتریت روماتوئید

Background: Exercise training is associated with improved health outcomes in many populations. It is assumed that exercise activities in the rheumatoid arthritis (RA) population may be reduced as a result of symptoms of the disease. The purpose of this study is survey of long-term effect of regular exercise on inflammatory changes in the RA population. Methods: In a randomized control trial, 30 women with RA randomly assigned to either an exercise (15 patient) and control groups (15 patient), respectively. 8-week program of exercise intensity was 65-75% of maximum heart rate exercise three days per week, each session a period 60 minutes were conducted. A fasting blood sample was collected 24 hours prior to, after 8 weeks and after 2 month of aerobic training from the patients. levels of C-reactive protein, complement proteins C3 and C4 were measured using standard methods. Analyze data at the level of alpha error of 5% was performed using SPSS version 17. Results: Results showed that there was a significant decline in levels of CRP and C4 after 12 weeks of regular in exercise group, but not in the control group. In this research About C3 level no significant difference was observed between the control group and exercise group.  Conclusion: These findings showed that aerobic training could reduce inflammation in patients with RA and consequently plays an important role in preventing the occurrence of cardiovascular disease in these patients. Keywords: Rheumatoid arthritis, Exercise training, acute phase proteins, Women