تاثیر پردنیزولون در جذب مایع گوش میانی

Background and purpose: The most common complication of acute otitis media (ÂÔM) is otitis media with effusion (ÔMË) in children. Ït’s definite cause is not known. Persistant otitis media for more than three months inspite of an appropriate course of antibiotic therapy, requires myringotomy to avoid probable complications. The purpose of this study is to evaluate the effect of oral prednisolone (1mg/kg body weight) on resolution of ÔMË in children before a surgical attempt. Materials and Methods: This experimental study was conducted on 49 patients with ÔMË for more than three months (approved by audiotympanometry) inspite of a two course broad spectrum antibiolic therapy. Ëxperimental group with 25 patients were treated with prednisolone in the dose of 1mg/kg/day for 10 days, and conrol group received only placebo for the same period. Statistical analysis was done using X2 test and clinical follow up was done for 2 week to 6 months. Results: Ôut of 25 patient in experimental group, 22(88%) of them had a resolusion of ÔMË, while in control group, out of 25 patients, the rate of resolusion was only 8(33.3%). The difference between two groups was statistically significant (P=0.0002, X= 13.19) and recurrence was not seen during the follow ups. Çonclusion: Âccording to the results obtained, Ït is recommended that a 10 days prednisolone therapy be tried in patients with ÔMË for more than three months duration, before a surgical attempt, if patient does not have any specific contra- indication for steroids therapy.