مطالعه اثرات دیابت مادری در ایجاد ناهنجاریهای جنینی در رت

The studies show that there are some embryonic malformation in &nbsp; &nbsp;maternal diabetic rats. This malformation may be manifestation in other &nbsp;&nbsp; embryonic organs such as skeletal cardiovascular or centeral nervus system.&nbsp; &nbsp;&nbsp; In this study the effects of the maternal hyperglicemia on the processes of &nbsp;&nbsp; embryonic evolution,&nbsp; during rat,s pregnancy were investigated. &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; For this aim the beta cells of pancreas&nbsp; of 7 virgin albino rats were &nbsp;&nbsp; chemically destroyed by an injection of 160 mg/Kg alloxan and the same &nbsp;&nbsp; manner control group were recived physiological serum. The hyperglicemic &nbsp;&nbsp; rats were then mated and at 14th gestational day&rsquo;s , all of the pregnant&nbsp; &nbsp;&nbsp; rats anesthetized, sacrificed and their&nbsp; fetuses were collected and fixed in &nbsp;&nbsp; 10% formalin solution.&nbsp; After fixation, all of the fetuses&nbsp; were examined by &nbsp;&nbsp; using the stereomicroscope. &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Comparing the experimental with the control group, showed a &nbsp;&nbsp; numerical decrease in experimental group.&nbsp; In addition, the length of&nbsp; &nbsp;&nbsp; Crown-Rump (CR) were decreased significantly in experimental fetuses &nbsp;&nbsp; (p<0.001). The rate of the many malformation such as deffect in eyes, ears &nbsp;&nbsp; and craniofascial deffect and exencephaly were shown in experimental &nbsp;&nbsp; kinds. &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; These results suggest that the maternal diabetic may cause some of&nbsp; &nbsp;&nbsp; fetal malformations during pregnancy.