مقایسه بین عوارض اعمال جراحی عروق با و بدون اندازه‌گیری aPTT و خنثی‌سازی هپارین با پروتامین

Background & Aim: clamp and also blood stasis during vascular surgeries. Heparin is administered to prevent thrombosis, and aPTT (activatedPartial Thromboplastin Time) test is used to make sure of anticoagulative effect of heparin. At the end of the operation,heparin is neutralized by protamin sulfate in some centers. In this study we assessed the necessity of aPTT and usingprotamin during vascular surgeries.Thrombosis occurs when blood comes into contact with unepithelialized surfaces after vascularPatients and Method: were matched regarding age and underlying diseases. The subjects were monitored for vascular complications during thefirst postoperative 24 hours. In group A (62 cases), aPTT was determined after 2 minutes of heparin administration butheparin was not neutralized by protamin at the end of the operation. In group B (92 cases), aPTT was not determined afterheparin administration but heparin was neutralized by an appropriate dose of protamin at the end of the operation. Toobtain mean and frequency the data were analyzed descriptively and analytical techniques such as Chi-square and t-testwere implemented using SPSS 14.In this case-control survey, 154 cases of vascular surgery were divided into two groups whichResults: ischemia in 1 case (0.65%), left leg neuropathy in 1 case (0.65%), and hypotension due to protamin in 1 case (0.65%). 3cases were from group A and 1 case was from group B. Nevertheless, the observed difference was not statisticallysignificant although the power was high enough (power=70%).Vascular surgery complications were seen in 4 cases (26%): right leg embolus in 1 case (0.65%), spinalConclusion: principles, there is no need for aPTT assessment and protamin administration. This can reduce the cost, duration andcomplications of operation and prevent adverse effects of protamin.According to our findings, it seems by applying appropriate techniques and accomplishing surgical