مقایسه سطح مس ادرار 24 ساعته در زنان باردار مبتلا به پراکلامپسی با زنان باردار و غیرباردار سالم

  Introduction: P reeclampsia is an important cause of maternal and prenatal mortality and morbidity in the world. The etiology of this relatively common medical complication of pregnancy, however, remains unknown. Deficient or excessive level trace elements can be an adverse factor.   Objective: The aim of this study was to evaluate copper status in women with preeclampsia with a view to explore the possible contribution of this parameter to the etiology.   Materials and Methods: Sixty preeclamptic, sixty normotensive pregnant and sixty healthy non- pregnant women were enrolled in a case - control study. The 24- hour urine copper was compared among the women.   Results: There was significant difference in copper concentration of 24- hour urine among the three groups due to the difference between preeclamptic and normotensive pregnant women (12.19 ± 3.71 vs 5.69 ± 2.05, p<0.0001). A correlation was found between the copper concentration and outcome of pregnancy.   Conclusion: Our results are consistent with some previous reports. Prospective studies are needed to determine whether observed alternation in copper precede preeclampsia or the difference may be attributed to preeclampsia - related alternations in maternal trace metal metabolism.