ADENOSINE IN THE CENTRAL NERVOUS SYSTEM
Besides being a metabolite of nucleotides like ATP, adenosine is a mediator of neuronal function in the central nervous system. Its actions are mediated by at least three extracellular receptors. In this review different aspects of adenosine such as biosynthesis, release, inactivation and its receptors are discussed. It also covers pre- and postsynaptic effects as well as postreceptor mechanisms of adenosine. Finally, therapeutic aspects of this neuromodulator have been discussed.
besides being a metabolite of nucleotides like atp, adenosine is a mediator of neuronal function in the central nervous system. its actions are mediated by at least three extracellular receptors. in this review different aspects of adenosine such as biosynthesis, release, inactivation and its receptors are discussed. it also covers pre- and postsynaptic effects as well as postreceptor mechanism...متن کامل
The adenosine receptors (ARs) in the nervous system act as a kind of "go-between" to regulate the release of neurotransmitters (this includes all known neurotransmitters) and the action of neuromodulators (e.g., neuropeptides, neurotrophic factors). Receptor-receptor interactions and AR-transporter interplay occur as part of the adenosine's attempt to control synaptic transmission. A(2A)ARs are...متن کامل
Listeriosis is one of the CNS inflammatory diseases which is happened majority in the form of sporadic. Listeriosis is ingested with the food. Infection occurrence in an exposed person depends on the number of organisms ingested, the virulence of the organisms strain and the individual condition. It is known that Listeriosis has decisive importance as an infection which the cellular immunodefen...متن کامل
A major problem for neuroscientists and clinicians is why the central nervous system shows ineffective regeneration after injury. Injured peripheral nerve fibers reform their connections, whereas those in injured spinal cord never re-grow. Insights into the mechanisms for repair and restoration of function after spinal cord injury have been obtained by experiments showing that injured nerve cel...متن کامل
In the process of neuronal inflammation, an increased in inflammatory cytokines (IL-1β, IL-6 and TNF-α) from immune cells (leukocytes and macrophages), brain cells (microglia, astrocytes and neurons) and in hippocampus, amygdala occurs. Raise the level of cytokines result in reduced in production of molecules that are related to plasticity, especially BDNF, IGF-1 and VEGF. Microglia ...متن کامل
In this investigation the effects of excess vitamin A administration during the early embryonic period were studied. Intramuscular injection of a single dose of 15000,20000 or 25000 IU/kg vitamin A to pregnant Balb/c strain mice on either day 7,8,9 or 10 of gestation (vaginal plug= day 0 of gestation) produced major malformations in the central nervous system (CNS) including exencephaly, h...متن کامل
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دوره 9 شماره 4
صفحات 361- 368
تاریخ انتشار 1996-02
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