Altered Testicular Histomorphometric and Antioxidant Levels Following in vivo Bisphenol-A Administration
Background: Bisphenol-A (BPA) is a pervasive environmental toxin that is used in the production processes of many consumables and equipment that are in daily application. The aim of this study was to determine the effects of BPA on the structural and functional integrity of the reproductive system in male Wistar rats and its interaction with melatonin. Methods: Adult female rats in pro-estrus phases were mated with adult male rats and the conception determined. The male pups were divided into two groups of A and B. These groups were further subdivided into six subgroups each. They were administered varying low doses of BPA (25 or 50 mg/kg) and melatonin (10mg/kg) at neonatal and adolescent ages. The testes, epididymis and blood samples were collected for histological, semen and biochemical investigations, respectively. Results: The results show that BPA caused histological alterations, reduced quality and quantity of sperm cells, and induced oxidative stress at birth and adolescence. Conclusions: Bisphenol A exposure, even at low dose, is toxic to the male reproductive system, and melatonin administration did not significantly improve the alterations caused by the BPA.
In Vivo Detection of Altered GABA Levels Following Acute Administration of Antidepressant/Antipanic Drug Phenelzine
J. Yang, J. Shen NIMH, Bethesda, MD, United States Introduction Phenelzine is a non-selective monoamine oxidase inhibitor which is efficacious in the treatment of depression, social phobia and panic disorders. As a potent inhibitor of both MAO-A and MAO-B, administration of phenelzine increases brain levels of the amine neurotransmitters noradrenaline, dopamine, and serotonin, which has been th...متن کامل
P-13: Histomorphometric Changes of The Skin in Rats Following Administration of Testosterone and Nettle
Testosterone is one of the important androgen. It has been reported that testosterone can have effects on hair follicles, dermal fibroblasts and interfollicular keratinocytes in vitro conditions. The purpose of this study is to investigate the effects of testosterone and nettle on skin structures and sebaceous glands. Materials and Methods: For this study, 20 healthy adult male wistar rats with...متن کامل
Histomorphometric evaluation of mice testicular tissue following short- and long-term effects of lipopolysaccharide-induced endotoxemia
Objective(s):Lipopolysaccharide (LPS)-induced endotoxemia is known to cause male infertility. This study was designed to explore the effects of bacterial LPS on histomorphometric changes of mice testicular tissues. Materials and Methods: In experiment 1, a pilot dose responsive study was performed with mice that were divided into five groups, receiving 36000, 18000, 9000, and 6750 µg/kg body...متن کامل
Evaluation of histopathologic and histomorphometric changes of testicular tissue and gonadotropin levels following consumption of methylphenidate in male mice.
BACKGROUND/AIM One of the most common psychiatric disorders in children is attention-deficit/hyperactivity disorder, which is treated extensively by methylphenidate. This study investigates the assessment of the effects of methylphenidate on histopathologic and histomorphometric changes of the testes and serum levels of gonadotropin in mice. MATERIALS AND METHODS In this study, 36 adult male ...متن کامل
P44: The Antioxidant Effect of Nanomicelle Curcumin in Bisphenol A-Induced Brain Toxicity Following Subacute Exposure in Rats
Bisphenol A (BPA) is used in the manufacture of polycarbonate plastics and epoxy resins; therefore, exposure to BPA is increasing every day. BPA has toxic effects on various human tissues. Curcumin, a yellow polyphenol, is the active turmeric ingredient. It is an efficacious and safe compound with multiple pharmacological activities including antioxidant, ant carcinogenic, ant proliferative, an...متن کامل
Efficiency of naringin against reproductive toxicity and testicular damages induced by bisphenol A in rats
Objective(s): Bisphenol A (BPA) as a synthetic compound is applied in many plastic industries. BPA has been reported to have endocrine-disrupting feature with cytotoxic effects. The study aimed to evaluate the efficiency of Naringin against testicular toxicity induced by BPA in adult rats.Materials and Methods: The animals were assigned into six groups of control, BPA-treated (50 mg/kg), BPA+Na...متن کامل
دوره 15 شماره 3
صفحات 0- 0
تاریخ انتشار 2021-07
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