Antibacterial Activity of Salvia reuterana Constituents

Two flavonids: 5-hydroxy-6,7,4 ́-trimethoxy flavone (salvigenin), 5-hydroxy-7,4 ́-dimethoxy flavone(thitonine) and a labdane type diterpenoid: 8,13-epoxy-14 labdene (manoyl oxide) isolated from the solventextract of the aerial part of Salvia reuterana Boiss.The proposed structure were stablished by 1HNMR,13CNMR, 2DNMR( C-H-Cosy, HMQC),DEPT and Mass spectroscopy and confirmed in accordance withbibiliographic data and computational chemistry results. The three components were evaluated against 7microorganisms including gram(+/-)bacterias by measurment of growth inhibitory zone. They showedsignificant effect specially on gram(-) bacterias and in this way the most effective component was thitoninewhich was even more effective than Gentamicine as standard antibiotic.