Antimalarial assessment of Viola odorata L. by heme polymerization inhibition method

Inhibition of Heme Polymerization, the Mechanism of Antimalarial Activity in Phlomis caucasica Rech.f. (Lamiaceae)

Background: Malaria is one of the most important parasitic diseases in the world caused by Plasmodium species. The malaria parasite digests hemoglobin in vacuole to amino acids and heme. Plasmodium has got several detoxification mechanisms to protect itself from toxic heme. The most important mechanism is heme polymerization. Identifying compounds that inhibit heme polymerization is an approach...

Phytochemical and Pharmacological Potential of Viola Odorata

Sweet violet also known as the Viola odorata, blooms in continental climate conditions in early spring with delicate flowers of attractive scent. It has been traditionally the part of various indigenous preparations and being used to cure respiratory and inflammatory conditions. Present review article is an attempt to cover recent developments in phytochemical and pharmacological potential of d...

Inhibition test of heme detoxification (ITHD) as an approach for detecting antimalarial agents in medicinal plants

Background and objectives: There are several methods to assess the in vitro capability of heme inhibitory activity of antimalarial compounds; most of them require some specific equipment or toxic substances and sometimes the needed materials are not accessible. Regarding the necessity and importance of optimizing and standardizing experimental conditions, the present s...

Relationship between antimalarial drug activity, accumulation, and inhibition of heme polymerization in Plasmodium falciparum in vitro.

We have investigated the contribution of drug accumulation and inhibition of heme polymerization to the in vitro activities of a series of antimalarial drugs. Only those compounds exhibiting structural relatedness to the quinolines inhibited heme polymerization. We could find no direct correlation between in vitro activity against chloroquine-susceptible or chloroquine-resistant isolates and ei...

Diuretic, Laxative and Toxicity Studies of Viola odorata Aerial Parts

Efficacy of Viola odorata in Treatment of Chronic Insomnia

BACKGROUND Insomnia is the most common sleep disorder that reduces quality of life. OBJECTIVES Due to side effects of hypnotic drug and the increasing demand for alternative medicine substitutes, violet oil (VO) was used in this study. VO is a known medication in Iranian traditional medicine that induces sleep in insomniac patients. PATIENTS AND METHODS This study was conducted as an experi...