ANTINEUTROPHIL CY TOPLASMIC AUTOANTIBODIES IN SYSTEMIC LUPUS ERYTHEMATOSUS

نویسندگان

  • F NASSIRI ZADEH
  • J HADJATI
  • M AKBARlAN
  • M VODJGANI From the Dept. of lmmunology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
چکیده مقاله:

Antineutrophil cytoplasmic autoantibodies (ANCA) were first described in patients with necrotizing glomerulonephritis. The original observation passed unnoticed until an association was made between ANCA and active Wegener's granulomatosis. Since then, tremendous progress has been made in elucidating the association between ANCA subtypes and clinicopathologic syndromes, and the potential pathologic role of ANCA in vascular inflammation. The gold standard method for ANCA detection is indirect immunofluorescence (IIF) microscopy of ethanol-fixed cells. By this technique two general patterns of ANCA, acytoplasmic pattern (c-ANCA) and a perinuclear pattern (P-ANCA) can be identifed. Recently some reports have been published concerning the prevalence, subtypes, role and specificity of ANCA.ln this study we searched for ANCA prevalence, subtypes, and its relationship with disease activity in SLE patients by IIF technique. Our results showed that all normal subjects were ANCA negative, while at least 50% of patients were ANCA positive (majority c-ANCA type). Statistical analysis revealed that there is no correlation between the presence of ANCA and disease activity (p<0.01).

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

antineutrophil cy toplasmic autoantibodies in systemic lupus erythematosus

antineutrophil cytoplasmic autoantibodies (anca) were first described in patients with necrotizing glomerulonephritis. the original observation passed unnoticed until an association was made between anca and active wegener&apos;s granulomatosis. since then, tremendous progress has been made in elucidating the association between anca subtypes and clinicopathologic syndromes, and the potential p...

متن کامل

Neurobrucellosis in systemic lupus erythematosus

Background: Brucellosis is a zoonotic infection which is endemic in many countries. It is a multisystem disease which may present with a broad spectrum of clinical manifestations and complications. Neurobrucellosis&nbsp;is an uncommon complication of brucellosis. Case presentation: A 25-year-old woman with a history of lupus for 5 months referred to the emergency ward of Shahid Beheshti Hosp...

متن کامل

Liver abnormalities and liver membrane autoantibodies in systemic lupus erythematosus.

The hepatic involvement of 57 patients with systemic lupus erythematosus (SLE) was studied with special reference to liver membrane autoantibody (LMA). Liver abnormalities were found predominantly in patients with active SLE (27/48 (56%) in active SLE v 3/20 (15%) in inactive SLE). They were, however, rather mild or moderate and tended to disappear as the disease activity of SLE decreased. In t...

متن کامل

Autoantibodies and neuropsychiatric manifestations in childhood-onset systemic lupus erythematosus

Methods We included consecutive cSLE followed at the pediatric rheumatology unit of the State University of Campinas. Neurological manifestations were analyzed according to the ACR classification criteria. Cognitive evaluation was performed in all participants using Wechsler Intelligence Scale for children (WISC-III) and Wechsler Intelligence Scale for adults (WAIS), according to age and valida...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ذخیره در منابع من قبلا به منابع من ذحیره شده

{@ msg_add @}


عنوان ژورنال

دوره 11  شماره 1

صفحات  15- 17

تاریخ انتشار 1997-05

با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.

کلمات کلیدی

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023