Comment on Cisplatin-Induced Renal Impairment
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Sumatriptan ameliorates renal injury induced by cisplatin in mice
Objective(s): Cisplatin (Cis) is an anticancer compound, which is used for the treatment of various cancers. Sumatriptan (Suma) is a selective agonist of 5-hydroxytryptamine 1B/1D (5HT1B/1D) receptor, which is prescribed for the management of migraine. It is well-established that Suma has anti-inflammatory and antioxidant properties. We have explored the protective effe...
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Objective(s):The purpose of the present study was to investigate the protective effect of oxytocin on cisplatin (CP)-induced renal damage in rats. Materials and Methods: Fourteen adult Sprague Dawley rats, weighing 200 to 210, were administered by cisplatin (CP, 2 mg/kg/day) twice a week for five weeks. Then, they were randomly divided into two groups and treated with either saline (1 ml/kg/day...
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*Corresponding author: Ali Ghorbani M.D, Department of Nephrology, Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. E-mail: [email protected] Implication for health policy/practice/research/medical education: Selenium supplementation reduces the products of oxidative stress in kidney failure patients and can be protective against cisplatin nephrotoxicity. ...
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BACKGROUND Cisplatin therapy is effective against many tumours, however, the nephrotoxicity of this drug is a dose-limiting factor. Apoptosis and necrosis of tubular cells and inflammatory events contribute to the cisplatin-induced nephrotoxicity. Cisplatin promotes increased production of reactive oxygen species, which can activate c-jun N-terminal kinase (JNK) that is a mediator of apoptosis ...
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AIM To investigate the influence of Montelukast (MK) in acute renal failure (ARF) experimentally induced by cisplatin (CIS). MATERIAL AND METHODS The experiment was carried out in male Wistar rats (280-320g), divided into 4 groups of 12 animals each, treated as follows: Group I (Control); Group II (CIS): CIS, 5 mg/kbw, single dose, i.p.; Group III (CISMK): CIS, 5 mg/kbw, single dose, i.p and ...
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Background and objective: Ficus benghalensis is a remarkable tree that sends down its branches and great number of shoots. It is used for treatment of neuralgia, rheumatism, lumbago, bruises, nasitis, gonorrhoea, inflammations, cracks of the sole and skin diseases and in ayurveda for diarrhea, dysentery, and piles”. To evaluate protective activity of F. benghalensis latex extract (FBLE) on cisp...
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عنوان ژورنال
دوره 7 شماره 1
صفحات 28- 28
تاریخ انتشار 2018-03-20
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