Detection of Extended Spectrum Beta Lactamase Producing Salmonella spp. and Multidrug Resistance Pattern
Background: and Objectives: Salmonella infections are endemic in many developing countries with poor sanitary conditions, but emerge sporadically as a serious public health threat in developed countries. Infections with multidrug resistant (MDR) strains of Salmonella have been associated with treatment failures. Salmonella spp. resistant to extended spectrum cephalosporins are increasing in prevalence worldwide. The aim of this study was to determine the antimicrobial susceptibility, multidrug resistance and extended spectrum beta lactamase (ESBL) production among clinical isolates of Salmonella spp. during 2007 in Tehran, Iran. Patients and Methods: In this cross-sectional study, fifty Salmonella spp. were identified by API 20E system and serotyped by the slide agglutination test. Disk diffusion test was performed. Double disk synergy test was used as a screening test for ESBL production, using disks of cefotaxime and ceftazidime with and without clavulanic acid. Results: From 50 Salmonella spp. 12 (24%) were S. enterica serotype paratyphi B, 24 (48%) S. enterica serotype paratyphi C and 14 (28%) were S. enterica serotype Typhi. The most susceptibility and resistance were observed to ceftazidime (98%) and amoxicillin-clavulanic acid (96%), respectively. 28(56%) were resistant to 5 or more antibiotics. ESBL production was detected by double disk synergy test in one isolate (2%). Conclusion: Results showed increase in antibiotic and multidrug resistance pattern of Salmonella spp. comparing to previous studies in Iran and other countries.It seems that this is the first report of Salmonella spp. ESBL producing in Iran.
detection of extended spectrum beta lactamase producing salmonella spp. and multidrug resistance pattern
background: and objectives: salmonella infections are endemic in many developing countries with poor sanitary conditions, but emerge sporadically as a serious public health threat in developed countries. infections with multidrug resistant (mdr) strains of salmonella have been associated with treatment failures. salmonella spp. resistant to extended spectrum cephalosporins are increasing in pre...متن کامل
Evaluation of a chromogenic medium for rapid detection of extended spectrum beta-lactamase producing Salmonella spp.
BACKGROUND & OBJECTIVES Salmonella spp. resistant to second- and third-generation cephalosporins and related antibiotics by production of various extended-spectrum beta-lactamases (ESBLs) are on the rise in Turkey. Early detection of ESBL producing Salmonella is important to institute appropriate treatment in time. In this study rapid detection of ESBL production among clinical isolates of Salm...متن کامل
Antimicrobial Pattern and Clonal Dissemination of Extended-Spectrum Beta-Lactamase Producing Klebsiella Spp Isolates
Problem statement: Gram-negative pathogens harboring ESBLs have caused numerous outbreaks of infections and are becoming an increasing therapeutic problem in many countries. The incidence of ESBL-producing strains among clinical isolates has been steadily increasing over the past years resulting in limitations of therapeutic option. The focus of this study was to examine the molecular epidemiol...متن کامل
Integron mediated multidrug resistance in extended spectrum beta-lactamase producing clinical isolates of Klebsiella pneumoniae
The present study describes integron mediated multiple antibiotic resistance in extended-spectrum β-lactamase producing clinical isolates of Klebsiella pneumoniae. One hundred and four clinical isolates of K. pneumoniae from two Iranian hospitals were screened for extended-spectrum β-lactamase production and susceptibility of the extended-spectrum β-lactamase producing isolates was determined t...متن کامل
Characterization of multidrug-resistant, qnrB2-positive and extended-spectrum-beta-lactamase-producing Salmonella Concord and Salmonella Senftenberg isolates.
OBJECTIVES To characterize plasmids and resistance genes of multidrug-resistant (MDR) Salmonella Senftenberg and Salmonella Concord isolated from patients in the Netherlands. METHODS The resistance genes of four MDR Salmonella isolates (three Salmonella Concord and one Salmonella Senftenberg) were identified by miniaturized microarray, PCR and sequencing. Plasmids were characterized by S1 nuc...متن کامل
دوره 4 شماره 3
صفحات 128- 132
تاریخ انتشار 2009-06-01
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