Evaluation of Bone Changes in Patients with Pseudoexfoliation Syndrome

Purpose: To evaluate the association of osteoporosis and pseudoexfoliation syndrome. Methods: This case-control observational study was conducted on patients admitted to Baghaee Poor eye clinic of Shahid Sadoughi Hospital, Yazd, in 2015. The case group included 35 patients diagnosed with pseudoexfoliation syndrome and the control group included 35 patients with no evidence of pseudoexfoliation syndrome. Patients in both groups underwent bone densitometry. All questionnaires were completed by a physician. Finally, the results of the two groups were analyzed. Results: There was a statistically significant difference between the mean lumbar spine bone mineral density in both groups (P=0.002; 95% CI: -0.82- -0.02), so that the mean for spinal bone density was -2.57±0.36 in the case group, and -1.48±0.02 in control group and difference between groups was -1.09±0.028. Moreover, the results showed no significant relationship between age and sex with incidence of osteoporosis in patients with pseudoexfoliation syndrome (P>0.05). Conclusion: The patients with pseudoexfoliation syndrome, compared with controls who did not have the syndrome, were under higher risk for developing osteoporosis. So, doing regular examinations in patients with pseudoexfoliation syndrome and in cases of high suspicion measurement of bone density could prevent developing osteoporosis among those patients.