Hyperendemic goiter in the Raviz of Rafsanjan, are there another unknown goiterogens?

Introduction: Endemic goiter due to lodine deficiency is one of the health problems in developing cointries includs Iran. So, national committee for control of lodine dificiency disorders has been planed salt lodinization program from 1368. The purpose of this study was to evaluate goiter status and it’s relation with urinary lodine excretion in schoolchildren in vill of Raviz (Raviz includs 6 smal – villages) of Rafsanjan.   Methods: 320 schoolchildren (boys and girls) the age of 6-12 years, those were whole schoolchildren in the Raviz, were examined for goiter and classified according to WHO classification and their urinary lodine excretion was measured. Also, drinking water lodine of Raviz was measured. Results: 87.34% of girls and 81.47% of boys had different grades of goiter, but, the majority were found grade I and since II. 25% of schoolchildren had severe urinary lodine defeciency (<2ug/dl), 4.4% moderate (2.1-4.9ug/dl) and 10.3% mild (5-9.9 ug/dl). The concentration of urinary lodine in 60.3% of schoolchildren were more than 10ug/dl (normal). Of 6 small – villages of vill of Raviz which this study were carried out there, only in one of them, concentration of lodine in the drinking water was 15.2 ug/dl, but in others were less than 2ug/dl.   Discussion:Although , the concentration of lodine in drinking water in 5 small-villages of Raviz were less than 2mg/dl, but in 60.3% of schoolchildren urinary lodine were found normal. So lodized salt consumption have had considerable effects on control of lodine deficiency. In addition severe endemic goiter in this area is independent to lodine deficiency, or the period of time of lodized salt consumption was not enough. Another possibility is present of unknown goitrogens in this area that should be discovered by more study.   Key words: Goiter, disturbance due to lodine dificiency, goitrogen.