I-41: Chorionic Villus Sampling (CVS): An Invasive Method for Prenatal Diagnosis
نویسندگان
چکیده مقاله:
Background: Chorionic villus sampling(CVS) has a major role in prenatal diagnosis . It is an invasive diagnostic method in completion of primary prenatal screenings. This article is a report of our 8 years experience of CVS in Mashhad. Materials and Methods: We have done 1511 cases of invasive diagnostic procedure including 723 CVS which were included in our study and also 788 cases of amniocentesis. The gestational ages of the patients whom CVS were done for them were between 10 to 22 weeks based on the LMP. All CVS's were done by 19.5 G needles under Ultrasonographic real time guide using freehand method by a radiologist. Results: Mean gestational age at the time of procedure was 12.5 weeks. The most common cause of CVS application was due to beta thalassemia (81%) followed by karyotype (7%), spinal muscular atrophy(werding Hoffman syndrome) (3.3%), Congenital adrenal hyperplasia (2.7%), Duchene muscular dystrophy (3%), and hemophilia, achondroplasia,paternity test, cystinuria, PKU in remaining cases. Needle insertions into placenta were done for 1 time in 517 patients (71.5%), 2 times in 163 patients (22.5%), 3 times in 38 patients (5.2%) and 4 times in 5 patients (0.7%). Any gestational complications within 1 months of CVS were considered as the complication of our procedure.As the complication of the CVS there were 13 cases of spotting without miscarriage (1.8%) and 5 cases of miscarriage (0.7%) including 3 cases of fetal death (0.4%) and one case of abortion (0.1%). Conclusion: CVS is considered as an invasive diagnostic method in early pregnancies but it's benefits outweighing the complications in all cases that it is indicated.
منابع مشابه
Invasive Prenatal Diagnosis: Chorionic Villus Sampling
Chorionic villus sampling (CVS) is the method of choice for first trimester invasive prenatal diagnosis. In expert hands, it is nowadays considered as safe as amniocentesis and has the advantage of an earlier diagnosis. In this review, we des cribe the technique of the procedure, its indications and contra indications and the requirements concerning adequate training and optimum clinical practi...
متن کاملPrenatal Genetic Diagnosis through Chorionic Villus Sampling
Chor ion ic v i l l us sampl ing (CVS) i s a technique for prenatal diagnosis of the fetal karyotype through cytogenetic analysis, and of Mendelian inherited diseases through molecular or biochemical analysis. Because the sampling technique can be performed in the first-trimester of pregnancy and diagnostic results can be obtained earlier than with amniocentesis, it has been utilized by clinici...
متن کاملTransabdominal chorionic villus sampling (CVS) for prenatal diagnosis of genetic disorders.
OBJECTIVE To determine the safety and outcome of transabdominal Chorionic Villus Sampling (CVS) for prenatal diagnosis of genetic disorders. DESIGN Descriptive study. PLACE AND DURATION OF STUDY Department of Pathology, PNS Shifa, Karachi, from January 2003 to December 2004. PATIENTS AND METHODS A total of 143 couples with request for prenatal diagnosis of various genetic disorders were s...
متن کاملAmniocentesis and chorionic villus sampling for prenatal diagnosis.
BACKGROUND A major disadvantage of second trimester amniocentesis is that the result is usually available only after 18 weeks' gestation. Chorionic villus sampling (CVS) and early amniocentesis can be done between 9 and 14 weeks and offer an earlier alternative. OBJECTIVES The objective was to assess comparative safety and accuracy of second trimester amniocentesis, early amniocentesis, trans...
متن کاملConsequences of Amniocentesis and Chorionic Villus Sampling for Prenatal Diagnosis
Cederholm, M. 2002. Consequences of amniocentesis and chorionic villus sampling for prenatal diagnosis. Acta Universitatis Upsaliensis. Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1118, 43 pp. Uppsala. ISBN 91554-5225-6. Amniocentesis (AC) and chorionic villus sampling (CVS) are the principal methods for fetal karyotyping. The aim of this thesis was to evaluate...
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عنوان ژورنال
دوره 7 شماره 3
صفحات 19- 19
تاریخ انتشار 2013-09-01
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