Immunohistochemical Comparison of p53 Expression, Intensity and Distribution in Different Papillary Urothelial Cancers

نویسندگان

  • Esmaeeli , Abdolhamid Department of Pathology, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
  • Keshavarzi , Saman Department of Pathology, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
  • Montazeri , Hamed Department of Pharmacognosy and Pharmaceutical Biotechnology, School of Pharmacy, Iran University of Medical Sciences, Tehran, Iran
  • Seyedabadi , Mohammad Department of Pathology, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran<br>Department of Toxicology and Pharmacology, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran<br>Pharmaceutical Sciences Research Center, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
  • Tanha , Kaveh Department of Medical Physics and Biomedical Engineering, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
چکیده مقاله:

Background: Given the importance of differential diagnosis of different papillary urothelial cancers, expression, intensity and distribution of p53 were evaluated in different bladder cancers using immunohistochemistry. Materials and Methods: In a retrospective study, archived samples of patients with different papillary urothelial cancers in Shohaday-e-Khalij Fars Hospital were selected. The samples were grouped according to the reported diagnosis into papilloma, low-malignant potential papillary tumors, low-grade papillary carcinoma, and high-grade papillary carcinoma. The samples were then immunohistochemically stained for p53.  Results: The majority of patients with papillary urothelial carcinoma were positive for p53. However, they were different in terms of intensity (p<0.001) and distribution (p<0.01). Low-malignant potential and low-grade malignant samples demonstrated low levels of p53 expression, whereas high-grade malignant samples exhibited high levels of its expression. Comparison of p53 distribution revealed focal expression in low-malignant potential group and diffused expression in malignant groups. Conclusion: The results of this study suggest p53 expression, intensity and distribution as a useful marker for differential diagnosis and therapeutic management of different urothelial cancers.

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عنوان ژورنال

دوره 25  شماره 2

صفحات  105- 113

تاریخ انتشار 2022-05

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