INFLUENCE OF NERVE TISSUE-DERIVED NEUROTRANSMITTERS ON MAST CELL MIGRATION
نویسندگان
چکیده مقاله:
In vitro culture systems using bone marrow cells from BALB/C mice were set up in medium supplemented with spleen-derived medium. Bone marrow cells grown in spleen-derived medium gave rise to cultures containing >97% mast cells. The cells were used in polarisation chemotaxis assays with the intention of determining the effect of nerve tissue-derived neurotransmitters on mast cell migration. Some available neurotransmitters including (substance-p, histamine, serotonin, Dopa, noradrenaline, acetylcholine, aspartic acid, epinephrine and nerve extracts) were tested. Mast cells showed a significant morphological response to 10-3 and 10-4 M histamine, 10-9 M serotonin, and 10'2 M Dopa Nerve extracts induced some shape changes in mast cells.
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influence of nerve tissue-derived neurotransmitters on mast cell migration
in vitro culture systems using bone marrow cells from balb/c mice were set up in medium supplemented with spleen-derived medium. bone marrow cells grown in spleen-derived medium gave rise to cultures containing >97% mast cells. the cells were used in polarisation chemotaxis assays with the intention of determining the effect of nerve tissue-derived neurotransmitters on mast cell migration. some...
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عنوان ژورنال
دوره 14 شماره 4
صفحات 379- 383
تاریخ انتشار 2001-02
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