Introducing Genes With Significant Role in Migraine: An Interactomic Approach

نویسندگان

  • Mona Zamanian-Azodi Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Mostafa Rezaei-Tavirani Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Reza Mahmoud Robati Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
چکیده مقاله:

Introduction: Migraine is a severe kind of headache with the chance hereditary of 50%. Molecular studies can promote understanding of migraine pathophysiology. One of which is bioinformatics approach that could provide additional information related to the identified biomarkers.  Methods: In this research, migraine genes are studies in terms of interaction pattern to introduce important individuals. Through STRING database Plug-in in Cytoscape, candidate genes for migraine were retrieved and analyzed by related applications. Based on centrality and action types (expression, activation, and inhibition) genes were screened.   Results: Numbers of 33 central genes including seven hub-bottlenecks were identified which 70% of central genes were involved in expression action with each other. Activation was dominate action relative to inhibition between the central genes. Conclusion: The finding indicates that insulin is the most important gene relative to migraine. It seems regulation of metabolism play critical role in control of migraine. 

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عنوان ژورنال

دوره 10  شماره 4

صفحات  363- 372

تاریخ انتشار 2019-07

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