Investigating the anti-tumoral effect of curcumin on the mice in which Ehrlich ascites and solid tumor is created


  • Arzu Yay Department of Histology, Embriology, Erciyes University Faculty of Medicine, Kayseri, Turkey
  • Harun Ülger Department of Anatomy, Erciyes University Faculty of Medicine, Kayseri, Turkey
  • Mehtap Nisari Department of Anatomy, Erciyes University Faculty of Medicine, Kayseri, Turkey
  • Niyazi Acer Department of Anatomy, Erciyes University Faculty of Medicine, Kayseri, Turkey
  • Seher Yilmaz Department of Anatomy, Yozgat Bozok University Faculty of Medicine, Yozgat, Turkey
  • Şerife Alpa Department of Anatomy, Karatay University Faculty of Medicine, Konya,Turkey
  • Tolga Ertekin Department of Anatomy, Kocatepe University Faculty of Medicine, Afyon, Turkey
چکیده مقاله:

Objective(s): In this study, the effects of different doses of curcumin application on Ehrlich ascites tumor (EAT) created in the mice of BALB/c type were investigated.Materials and Methods: Curcumin extracts can have hindering effect on tumor volume, vascular density, EAT cells around the tissues, and can support apoptosis. EAT cells (1x106) received from stock animals were injected intraperitoneally (IP) and subcutaneously (SC) to the animals. Then, curcumin was administered IP. Doses of 25 mg/kg IP and 50 mg/kg were administered over 10 days to the animals in the treatment groups in which ascites tumor was induced. The same doses were administered over 15 days in the treatment groups in which solid tumor was induced.Results: Histopathological examination in ascites tumor groups revealed that number of EAT cells at surrounding tissues was smaller in the group received 50 mg/kg curcumin when compared to tumor control group (P

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عنوان ژورنال

دوره 22  شماره 4

صفحات  418- 425

تاریخ انتشار 2019-04-01

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