O-37: Yolk Sac Diameter and Embryonic Heart Rate As Prognostic Factors of First Trimester Spontaneous Miscarriage

Background: During the past 20 years a lot of information is achieved about the first trimester of pregnancy through ultrasound and intrauterine fertilization. Many researchers tried to use the symptoms of ultrasound in early pregnancy like measuring the gestational sac and yolk sac of the pregnancy to predict the continuation of pregnancy. Aim of the recent study is to predict the risk of spontaneous abortion at 8-6 weeks of pregnancy us ing ultrasound markers. Materials and Methods: This prospective and observational study was performed on 239 pregnant women admitted to Ayatollah Roohani Hospital in the years 2010-2012; pregnant women were enrolled with regular menstrual cycles (28-30 days). For all patients at 6-8 week of gestation vaginal ultrasound was performed and yolk sac diameter (YSD) and embryonic heart rate (HER) were evaluated. Then the patients were followed the end of 20 weeks of pregnancy. Results: Patients were followed up until 20th weeks, and 18 (7.5%) aborted. We evaluated the variables by receiver operator characteristic curve to predict abortion. The areas under the curve for EHR (0.95) and for YSD (0.80) were statistically significant (p< 0.023, p< 0.039 respectively). The logistic regression analysis was done to predict the risk of abortion during pregnancy and EHR were statistically significant (p< 0.003). Conclusion: EHR is more capable to predict the risk of abortion than yolk sac diameter in the first trimester.