P-123: The Effect of Salvia Officinalis Extract on Serum Levels of Testosterone and Testes Tissue Differentiation in Male Rats

s:1381:"Background: Studies show that Salvia officinalis administration can influence reproductive functions in animals. The purpose of this study was to determine the effects of Salvia officinalis extract on serum levels of testosterone and testes tissue differentiation in male rats. Materials and Methods: Male Wistar rats were randomly divided into control, normal saline, and Salvia officinalis extract receiving rats. Salvia officinalis extract (200 mg/Kg/day) was injected intraperitoneally for 30 days. Blood samples were collected using cardiac puncture method. Serum testosterone level was measured by radioimmunoassay method. Testes tissue were examine microscopically. Data were statistically analyzed and compared between groups using "one way- ANOVA". Results: The results indicated that serum testosterone level was significantly increased in Salvia officinalis receiving animals compared with control groups (p<0.001). Seminiferous wall diameter was significantly increased in Salvia extracts receiving animals compared with control rats (p<0.01). There was also higher number of spermatozoon in seminiferous tubules in Salvia extract receiving animals than control animals (p<0.001). Conclusion: Our findings show that Salvia officinalis extract has a potential to improve testicular spermatogenesis and increasing of testosterone level.";