P-23: Evaluation of Relation between Sperm DNA Fragmentation with IUI Outcomes

Background: Sperm chromatin integrity assessment has been suggested as fertility predictor. The aim of this study was to examine the relationship between the results of sperm chromatin structure assay (SCSA) and the outcome of intrauterine insemination IUI. Materials and Methods: A total of 576 consecutive couples undergoing IUI were included and IUI was performed. SCSA results were expressed as DNA fragmentation index (DFI) before and after processing. Reproductive outcome parameters were biochemical pregnancy (BP), clinical pregnancy (CP) and delivery (D). Results: The average of DFI before processing was significantly higher than those of DFI after processing (p<0.001). DFI was negatively correlated to sperm concentration, sperm total motility, type A and B motility and sperm morphology before processing and also, between DFI before and after processing. Conclusion: SCSA is a useful method for prediction of the outcome of IUI.