P-49: Comparative Appraisal of Acarbose, Pioglitazone and Repaglinide on Histopathology of Testis in Streptozotocin Induced Diabetic Rats

Background: Experimentally induced diabetes in male rats is associated with alteration in functions of reproductive system. Acarbose, Pioglitazone and Repaglinide via decrease in blood glucose level can prevent the damage of testes. Materials and Methods: A total of 96 adult male albino rats whit a body weighing between 230- 250 g were injected by a single intraperitoneal injection of streptozotocin (65 mg/kg Body weight.) and were randomly assigned to 4 groups and 4 replicates for each group. Group 1 served as diabetic Control, group 2 received Pioglitazone (10 mg/kg/day, orally), group 3 received Repaglinide (1 mg/kg/day, orally) and group 4 received Acarbose (25 mg/kg/day, orally) for a period of 7 days. At the end of the study period, testis samples were taken for histopathological investigations. spermatogonia, spermatocyte, spermatid and sertoli cells in all groups were calculated. Results: Reduction in number of espermatogonial cells, number of spermatocyte cells and sertoli cells in group 4 was less than other groups. Number of spermatid cells in animals treated with Repaglinide was more than other treatment groups. Conclusion: Results indicated that Acarbosehas is more effective for testis of adult diabetic rats by reducing histological Changes of testicular tissue and its negative effects on sperm production.