P124: Listeriosis in Central Nervous System
Listeriosis is one of the CNS inflammatory diseases which is happened majority in the form of sporadic. Listeriosis is ingested with the food. Infection occurrence in an exposed person depends on the number of organisms ingested, the virulence of the organisms strain and the individual condition. It is known that Listeriosis has decisive importance as an infection which the cellular immunodefense mediated by the T lymphocyte is disturbed. Even patients without previous disease worth indicating may be affected. The attribute of the many CNS manifestations are illustrated via the case histories (meningoencephalitis, acute meningitis, brain abscess, brain stem encephalitis, chronic recidivating encephalitis, meningoencephalitis with infected cerebral infarct). Neurological signs, combined with CSF findings atypical for bacterial CNS disease, must not be taken and may point to listeriosis even though they aren't specific for CNS listeriosis. The conclusive evidence is the proof of the Listeria in the blood or CSF or the proof of antibody titre changes in the serum. New CSF diagnostic procedure like CSF lactate determination and the recognition of IgG-positive B lymphocytes are suitable in differentiating between viral and noninflammatory CNS disease; the most important for consistency are repeation of CSF examinations. The therapy of choice in CNS listeriosis is high-dosage amoxycillin or ampicillin treatment combined with gentamycin. Estimation of chances of the listeriosis in CNS depends on the prior to disease in each case. The high mortality is at least in part due to delayed diagnosis.
Besides being a metabolite of nucleotides like ATP, adenosine is a mediator of neuronal function in the central nervous system. Its actions are mediated by at least three extracellular receptors. In this review different aspects of adenosine such as biosynthesis, release, inactivation and its receptors are discussed. It also covers pre- and postsynaptic effects as well as postreceptor mecha...متن کامل
In this investigation the effects of excess vitamin A administration during the early embryonic period were studied. Intramuscular injection of a single dose of 15000,20000 or 25000 IU/kg vitamin A to pregnant Balb/c strain mice on either day 7,8,9 or 10 of gestation (vaginal plug= day 0 of gestation) produced major malformations in the central nervous system (CNS) including exencephaly, h...متن کامل
Listeria monocytogenes (LM) causes a life-threatening infectious disease affecting the brain of humans and domestic animals. Unfortunately, no adequate murine models for CNS listeriosis exist. Using intraparenchymal injection, we have established a new murine model for CNS listeriosis. Injection of a small volume of bacterial suspension limits the bacteria to the brain parenchyma with no leakag...متن کامل
Background & Objectives: The accurate assessment of the diseased tissue is fundamental to the diagnosis and management of disorders of the central nervous system (CNS). The ‛squash’ or ‛crush’ technique has been universally employed in the intraoperative diagnosis of CNS tumors. The aim of our study was to evaluate the accuracy of squash preparation in diagnosing CNS tumors by comparing with hi...متن کامل
Systemic Lupus Erythematosus (SLE) is a complex clinical syndrome which its components are less clearly recognized and includes heterogeneous demonstrations engaging both central and peripheral nervous system along with disabling effects. This disease is called "thousand faces" due to these heterogeneous demonstrations. This gap exists while 75% of adults and children with SLE may dea...متن کامل
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دوره 6 شماره 2
صفحات 155- 155
تاریخ انتشار 2018-04
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