P48: Self-Assembling Peptide Nanostructures as a Good Scaffold for Treatment of Spinal Cord Injury
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p48: self-assembling peptide nanostructures as a good scaffold for treatment of spinal cord injury
to date, various approaches have been used in attempt to treat spinal cord injury (sci) but there is no definite treatment for repair of the damaged tissue. it is well known that sci results in a loss of neural tissues and formation of cystic cavities that inhibit regeneration of axons. tissue engineering, in which cells, signals and scaffolds are combined, is one of the most promising areas of...
متن کاملReknitting the injured spinal cord by self-assembling peptide nanofiber scaffold.
In traumatic spinal cord injury, loss of neurological function is due to the inability of damaged axons to regenerate across large, cystic cavities. It has recently been demonstrated that a self-assembled nanofiber scaffold (SAPNS) could repair the injured optical pathway and restore visual function. To demonstrate the possibility of using it to repair spinal cord injury, transplanted neural pr...
متن کاملP 41: Meningioma Stem Like Cells and Self Assembling Nanopeptide Scaffold for Treatment of Traumatic Brain Injury in Animal Model
Introduction: Brain injury is an important cause of morbidity and mortality worldwide and so far, there has been no absolute treatment for the damaged brain tissue. Using human stem cells with self-assembling scaffolds can be a promising method for treatment of traumatic brain injury. Materials and Methods: Human meningioma stem cells were isolated, cultured and then expanded into in vitro cond...
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متن کاملEvaluation of Early and Late Effects into the Acute Spinal Cord Injury of an Injectable Functionalized Self-Assembling Scaffold
The complex physiopathological events occurring after spinal cord injury (SCI) make this devastating trauma still incurable. Self-assembling peptides (SAPs) are nanomaterials displaying some appealing properties for application in regenerative medicine because they mimic the structure of the extra-cellular matrix (ECM), are reabsorbable, allow biofunctionalizations and can be injected directly ...
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Spinal fusion and bone defect after injuries, removal of bone tumors, and infections need to be repaired by implantation. In an aging society, recovery from these procedures is often difficult. In this study, we found that injection of SPG-178 leads to expression of several bone marker genes and mineralization in vitro, and revealed a significantly higher degree of newly formed bone matrix with...
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عنوان ژورنال
دوره 2 شماره 4
صفحات 98- 98
تاریخ انتشار 2014-12
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