P62: The Effect of Valproic Acid Therapy on the Glial Scar Formation after Acute Spinal Cord Injury Fallowing by Motor Vehicle Traffic Crashes
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P7: Valproic Acid Mediated Neuroprotection and Neurogenesis after Acute Spinal Cord Injury
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در این پژوهش به بررسی اثر افزایش ترافیک بر روی تعداد تصادفات پرداخته شده است. به این منظور 30 تقاطع در شهر تهران بطور تصادفی انتخاب گردید و تعداد تصادفات ماهیانه در این تقاطعات در طول سالهای 89-90 از سازمان کنترل ترافیک شهر تهران استخراج گردید و با استفاده از مدل داده های تابلویی و نرم افزار eviews مدل خطی و درجه دوم تخمین زده شد و در نهایت این نتیجه حاصل شد که تقاطعات پر ترافیک تر تعداد تصادفا...
15 صفحه اولUnderstanding the NG2 Glial Scar after Spinal Cord Injury
NG2 cells, also known as oligodendrocyte progenitor cells, are located throughout the central nervous system and serve as a pool of progenitors to differentiate into oligodendrocytes. In response to spinal cord injury (SCI), NG2 cells increase their proliferation and differentiation into remyelinating oligodendrocytes. While astrocytes are typically associated with being the major cell type in ...
متن کاملSelf-assembling nanofibers inhibit glial scar formation and promote axon elongation after spinal cord injury.
Peptide amphiphile (PA) molecules that self-assemble in vivo into supramolecular nanofibers were used as a therapy in a mouse model of spinal cord injury (SCI). Because self-assembly of these molecules is triggered by the ionic strength of the in vivo environment, nanoscale structures can be created within the extracellular spaces of the spinal cord by simply injecting a liquid. The molecules a...
متن کاملThe Neuroprotective Effect of Treatment of Valproic Acid in Acute Spinal Cord Injury
OBJECTIVE Valproic acid (VPA), as known as histone deacetylase inhibitor, has neuroprotective effects. This study investigated the histological changes and functional recovery from spinal cord injury (SCI) associated with VPA treatment in a rat model. METHODS Locomotor function was assessed according to the Basso-Beattie-Bresnahan scale for 2 weeks in rats after receiving twice daily intraper...
متن کاملp7: valproic acid mediated neuroprotection and neurogenesis after acute spinal cord injury
spinal cord injury (sci)-induced systemic inflammatory response affects multiple organs outside the spinal cord. treatment options for such complications are lacking. valproic acid (vpa) is a histone deacetylase inhibitor, acting directly at the level of gene transcription by inhibiting histone deacetylation and making transcription sites more accessible. acetylation of histones is critical to...
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عنوان ژورنال
دوره 2 شماره 4
صفحات 112- 112
تاریخ انتشار 2014-12
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