Plasma Level of miRNA-7, miRNA-409 and miRNA-93 as Potential Biomarkers for Colorectal Cancer
نویسندگان
چکیده مقاله:
Colorectal cancer (CRC) is among deadliest cancers all over the world. Regarding its high mortality, some researches have focused to discover new applicable diagnosis methods. In this regard, circulatory miRNAs has been received huge consideration as promising biomarkers for early detection of CRC. The study aimed to evaluate the expression level of miRNA-7, miRNA-93, and miRNA-409 in plasma of CRC patients compared to healthy controls. According to the results, miRNA-7 and miRNA-409 were significantly upregulated in plasma of CRC patients (p< 0.05) while miRNA-93 was insignificantly elevated in CRC patients (p> 0.05). Therefore, it seems that upregulation of miRNA-7, miRNA-93, and miRNA-409 is involved in CRC carcinogenesis. Additionally, miRNA-7 and miRNA-409 could be considered as novel potential biomarkers for CRC.
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عنوان ژورنال
دوره 5 شماره 1
صفحات 9- 16
تاریخ انتشار 2019-01-28
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