Preparation of [111In]-Bleomycin radiopharmaceutical [Persian]

نویسندگان

  • Alireza Karimian Cyclotron and Nuclear Medicine Department, Agricultural, Medical and Industrial Research School, Nuclear Science and Technology Research Institute, Atomic Energy Organization of Iran, Karaj, Iran
  • Amir Reza Jalilian Cyclotron and Nuclear Medicine Department, Agricultural, Medical and Industrial Research School, Nuclear Science and Technology Research Institute, Atomic Energy Organization of Iran, Karaj, Iran
  • Faraj Tabeie Shaheed Beheshti University of Medical Sciences, Tehran, Iran
  • Gholamreza Aslani Cyclotron and Nuclear Medicine Department, Agricultural, Medical and Industrial Research School, Nuclear Science and Technology Research Institute, Atomic Energy Organization of Iran, Karaj, Iran
  • Gholamreza Raisali Cyclotron and Nuclear Medicine Department, Agricultural, Medical and Industrial Research School, Nuclear Science and Technology Research Institute, Atomic Energy Organization of Iran, Karaj, Iran
  • Jamshid Moafian Cyclotron and Nuclear Medicine Department, Agricultural, Medical and Industrial Research School, Nuclear Science and Technology Research Institute, Atomic Energy Organization of Iran, Karaj, Iran
  • Mohammad Mirzaie Cyclotron and Nuclear Medicine Department, Agricultural, Medical and Industrial Research School, Nuclear Science and Technology Research Institute, Atomic Energy Organization of Iran, Karaj, Iran
  • Mohsen Kamali Dehghan Cyclotron and Nuclear Medicine Department, Agricultural, Medical and Industrial Research School, Nuclear Science and Technology Research Institute, Atomic Energy Organization of Iran, Karaj, Iran
  • Saeed Daneshvari Cyclotron and Nuclear Medicine Department, Agricultural, Medical and Industrial Research School, Nuclear Science and Technology Research Institute, Atomic Energy Organization of Iran, Karaj, Iran
  • Sedigheh Moradkhani Cyclotron and Nuclear Medicine Department, Agricultural, Medical and Industrial Research School, Nuclear Science and Technology Research Institute, Atomic Energy Organization of Iran, Karaj, Iran
چکیده مقاله:

In this study, the preparation of 111In-Bleomycin complex was optimized for temperature, time, concentration and pH during several experiments. The results showed that by the addition of bleomycin to 111In-InCl3 sample (dried under flow of N2) and heating the mixture up to 90-100°C the radiopharmaceutical can be obtained in 99.5% yield and a specific activity of 1.745 Ci/mmol. The final sample was injected into fibrosarcoma-bearing mice via their tail vein. Satisfactory preliminary SPECT images were acquired between 2-4 hours post-injection showing suitable accumulation in fibrosarcoma tumors.

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منابع مشابه

preparation of [111in]-bleomycin radiopharmaceutical [persian]

in this study, the preparation of 111in-bleomycin complex was optimized for temperature, time, concentration and ph during several experiments. the results showed that by the addition of bleomycin to 111in-incl3 sample (dried under flow of n2) and heating the mixture up to 90-100°c the radiopharmaceutical can be obtained in 99.5% yield and a specific activity of 1.745 ci/mmol. the final sample ...

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عنوان ژورنال

دوره 13  شماره 1

صفحات  19- 26

تاریخ انتشار 2005-01-01

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